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Open AccessExperimental evidence for temporal uncoupling of brain Aβ deposition and neurodegenerative sequelae
Brain Aβ deposition is a key early event in the pathogenesis of Alzheimer´s disease (AD), but the long presymptomatic phase and poor correlation between Aβ deposition and clinical symptoms remain puzzling. To ...
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Article
Acute targeting of pre-amyloid seeds in transgenic mice reduces Alzheimer-like pathology later in life
Amyloid-β (Aβ) deposits are a relatively late consequence of Aβ aggregation in Alzheimer‘s disease. When pathogenic Aβ seeds begin to form, propagate and spread is not known, nor are they biochemically defined...
