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Article
Open AccessNeddylation activated TRIM25 desensitizes triple-negative breast cancer to paclitaxel via TFEB-mediated autophagy
Paclitaxel (PTX) treatment resistance is an important factor leading to poor prognosis in triple-negative breast cancer (TNBC), therefore there is an urgent need to identify new target for combination therapy....
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Article
Open AccessEfficacy and safety of immune checkpoint inhibitors in solid tumor patients combined with chronic coronary syndromes or its risk factor: a nationwide multicenter cohort study
Although, immune checkpoint inhibitors (ICIs) have been widely applied in the therapy of malignant tumors, the efficacy and safety of ICIs in patients with tumors and pre-existing CAD, especially chronic coron...
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Article
Open AccessANXA9 facilitates S100A4 and promotes breast cancer progression through modulating STAT3 pathway
Breast cancer has the highest global incidence and mortality rates among all cancer types. Abnormal expression of the Annexin family has been observed in different malignant tumors, including upregulated ANXA9...
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Article
Open AccessHeterogeneous expression of ARID1A in colorectal cancer indicates distinguish immune landscape and efficacy of immunotherapy
AT-rich interaction domain 1A (ARID1A) mutant tumors show active anti-tumor immune response, which is the potential indication of immunotherapy. However, the relationship between the heterogeneous ARID1A expre...
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Article
Renewable energy consumption — financial globalization-tourism nexus with nonlinearity and cross-sectional dependence during Asia’s carbon-free transition
Adopting renewable energy consumption is one of the most important aspects of international efforts to combat climate change, improve energy security, and encourage the shift to a more robust and sustainable e...
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Article
Open AccessComparative chloroplast genomics of 24 species shed light on the genome evolution and phylogeny of subtribe Coelogyninae (Orchidaceae)
The orchids of the subtribe Coelogyninae are among the most morphologically diverse and economically important groups within the subfamily Epidendroideae. Previous molecular studies have revealed that Coelogyn...
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Living Reference Work Entry In depth
The Psychology of Science
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Living Reference Work Entry In depth
Humanistic Psychology
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Article
Open AccessImproved chromosome-level genome assembly of Indian sandalwood (Santalum album)
Santalum album is a well-known aromatic and medicinal plant that is highly valued for the essential oil (EO) extracted from its heartwood. In this study, we present a high-quality chromosome-level genome assembly...
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Article
Open AccessIdentification of HpMYB1 inducing anthocyanin accumulation in Hippeastrum Hybridum tepals by RNA-seq
Cultivated Hippeastrum × hybridum is a popular ornamental plant with large and colorful flowers, long flowering duration, and high commercial value. As its main ornamental feature, its flower color is related to ...
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Article
Open AccessACVRL1 drives resistance to multitarget tyrosine kinase inhibitors in colorectal cancer by promoting USP15-mediated GPX2 stabilization
Multitarget tyrosine kinase inhibitors (mTKIs) such as Regorafenib and Sorafenib have already been approved for the treatment of many solid tumours. However, the efficacy of mTKIs in colorectal cancer (CRC) is...
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Article
Open AccessRecombinant oncolytic adenovirus armed with CCL5, IL-12, and IFN-γ promotes CAR-T infiltration and proliferation in vivo to eradicate local and distal tumors
The efficacy of chimeric antigen receptor T (CAR-T) cells for solid tumors remains unsatisfactory due to the limited tumor infiltration and immunosuppressive microenvironment. To overcome these limitations, th...
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Article
Open AccessClinical presentations and outcomes of pancreaticobiliary maljunction in different pediatric age groups
Pancreaticobiliary maljunction (PBM) is a congenital defect, with risk of develo** various pancreaticobiliary and hepatic complications. The presentations of PBM in children and adults are believed to be dif...
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Article
Open AccessBiochar-based materials in environmental pollutant elimination, H2 production and CO2 capture applications
Biochar and biochar-based materials have been studied extensively in multidisciplinary areas because of their outstanding physicochemical properties. In this review article, biochar and biochar-based materials...
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Article
Study on the storage performance of MG30/NRL co-blended latexes
Modifying natural rubber latex (NRL) and blending it with NRL can improve NRL performance and expand application fields. The performance of co-blended latex will change due to changes in non-rubber components ...
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Article
Mitochondrial C1QBP is essential for T cell antitumor function by maintaining mitochondrial plasticity and metabolic fitness
The metabolic stress present in the tumor microenvironment of many cancers can attenuate T cell antitumor activity, which is intrinsically controlled by the mitochondrial plasticity, dynamics, metabolism, and ...
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Article
Open AccessComparative analyses and phylogenetic relationships of thirteen Pholidota species (Orchidaceae) inferred from complete chloroplast genomes
The orchid genus Pholidota Lindl. ex Hook. is economically important as some species has long been used in traditional medicine. However, the systematic status of the genus and intergeneric relationships inferred...
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Article
Open AccessCircRNF10-DHX15 interaction suppressed breast cancer progression by antagonizing DHX15-NF-κB p65 positive feedback loop
Breast cancer (BC) is a common threat to women. The continuous activation of nuclear factor kappa B (NF-κB) signaling pathway contributes to the development of BC. This study aimed to investigate the role of a...
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Article
Open AccessNodal promotes colorectal cancer survival and metastasis through regulating SCD1-mediated ferroptosis resistance
Re-expression of an embryonic morphogen, Nodal, has been seen in several types of malignant tumours. By far, studies about Nodal’s role in colorectal cancer (CRC) remain limited. Ferroptosis is essential for C...
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Article
Flame-retardant properties of chitin liquefaction-based polyurethane foam
The conversion of solid chitin into liquid low-molecular-weight polyol compounds using liquefaction technology can realize the high-value utilization of shrimp and crab shell marine waste. In this study, chiti...
