-
Article
Open AccessAnalysis of aged microplastics: a review
Microplastics are emerging contaminants that undergo progressive aging under environmental conditions such as sunlight irradiation, mechanical forces, temperature variations, and the presence of biological org...
-
Article
An Investigation of the Toxicity and Mechanisms of Food Additives Based on Network Toxicology and GEO Databases: A Case Study of Aspartame
This study employs network toxicology, molecular docking, and molecular dynamics simulations to assess the characteristics and potential molecular mechanisms of aspartame-induced hepatocellular carcinoma (HCC)...
-
Article
Open AccessTargeting a disintegrin and metalloprotease (ADAM) 17-CD122 axis enhances CD8+ T cell effector differentiation and anti-tumor immunity
CD8+ T cell immune responses are regulated by multi-layer networks, while the post-translational regulation remains largely unknown. Transmembrane ectodomain shedding is an important post-translational process or...
-
Article
Open AccessDietary ellagic acid therapy for CNS autoimmunity: Targeting on Alloprevotella rava and propionate metabolism
Mediterranean diet rich in polyphenolic compounds holds great promise to prevent and alleviate multiple sclerosis (MS), a central nervous system autoimmune disease associated with gut microbiome dysbiosis. Hea...
-
Article
Open AccessMandelonitrile lyase MDL2-mediated regulation of seed amygdalin and oil accumulation of Prunus Sibirica
The Prunus sibirica seeds with rich oils has great utilization, but contain amygdalin that can be hydrolyzed to release toxic HCN. Thus, how to effectively reduce seed amygdalin content of P. sibirica is an inter...
-
Article
Effect of Variable Rate Non-isothermal Aging on the Microstructure and Properties of Al-Zn-Mg-Cu Alloy
The effect of variable rate nonisothermal aging (VR-NIA) on the properties and microstructure of Al-Zn-Mg-Cu alloy was studied through testing, such as hardness, friction and wear, intergranular corrosion (IGC...
-
Article
Open AccessDevelopment of deaminase-free T-to-S base editor and C-to-G base editor by engineered human uracil DNA glycosylase
DNA base editors enable direct editing of adenine (A), cytosine (C), or guanine (G), but there is no base editor for direct thymine (T) editing currently. Here we develop two deaminase-free glycosylase-based b...
-
Article
Open AccessReview of clinical characteristics and mortality outcomes in patients on maintenance hemodialysis during the Omicron surge: a single center experience
This hemodialysis center experienced the pandemic from December 2022 to January 2023. Therefore, we sought to describe the clinical characteristics and mortality outcomes in hemodialysis patients during this O...
-
Article
Open AccessGlobal selection appraisal study for heat pump system of electric vehicle based on energetic, economic, and environmental analysis
The development of electric vehicles (EVs) exhibits rapid and remarkable progress nowadays, serving as a crucial route to accomplish the target of mitigating greenhouse gas emissions. As an integral part of th...
-
Article
Open AccessEnthesitis and Dactylitis Resolution with Risankizumab for Active Psoriatic Arthritis: Integrated Analysis of the Randomized KEEPsAKE 1 and 2 Trials
The presence (vs absence) of enthesitis/dactylitis is associated with greater psoriatic arthritis (PsA) activity and reduced health-related quality of life. Risankizumab, an interleukin 23 antagonist, demonstr...
-
Article
Efficacy and safety of proton pump inhibitors on cardiovascular events and inflammatory factors in patients with upper gastrointestinal bleeding undergoing dual antiplatelet therapy
This work evaluated the effects of proton pump inhibitors (PPIs) on cardiovascular events (CVEs) and inflammatory factors in patients with upper gastrointestinal bleeding (UGIB) undergoing dual antiplatelet th...
-
Article
HIV Services Uptake Among People Living with HIV in Jiangsu Province, China: A Cross-Sectional Study
Healthcare disparities are common among people living with HIV (PLWH) in China and likely impact access to HIV services. This study aimed to assess the current status of access to HIV services among PLWH and e...
-
Article
Open AccessA lightweight and personalized edge federated learning model
As a new distributed machine learning paradigm, federated learning has gained increasing attention in the industry and research community. However, federated learning is challenging to implement on edge device...
-
Article
Effects of Nitrogen Fertilizer Reduction Combined with Foliar Fertilizer Application on the Physiological Characteristics and Yield of High-Quality Japonica Rice
High-quality japonica rice, distinguished by its unique flavor and enriched nutritional value, has attracted significant attention across Asia. The over-application of nitrogen (N) fertilizers, however, is a g...
-
Article
Effect of Different Mg2Si Concentrations on the Wear Properties and Microstructure of Mg2Si/Al–5 wt.% Cu Composites
In this paper, x wt.% Mg2Si/Al–5 wt.% Cu (x = 5, 10, 15, 20, and 25) composites were prepared by an in situ process. The effect of phase content of Mg2Si on their microstructures and performances was investigated...
-
Article
Open AccessComparison of children and adults in deep brain stimulation for Tourette Syndrome: a large-scale multicenter study of 102 cases with long-term follow-up
Deep brain stimulation (DBS) is a promising therapy for refractory Gilles de la Tourette syndrome (GTS). However, its long-term efficacy, safety, and recommended surgical age remain controversial, requiring ev...
-
Article
Open AccessTertiary lymphoid structures as a potential prognostic biomarker for combined hepatocellular–cholangiocarcinoma
Combined hepatocellular–cholangiocarcinoma (cHCC–CCA), as a rare primary hepatic tumor, is challenging to accurately assess in terms of the clinical outcomes and prognostic risk factors in patients. This study...
-
Article
Effect of Thermal Cold Cycling on the Microstructure and Properties of Al–Cu–Mg–Ag Alloy
To study the effect of thermal cold cycling on the microstructure and properties of Al–Cu–Mg–Ag alloy, hardness and tensile tests, resistivity tests, friction and wear tests, intergranular corrosion, and elect...
-
Article
Open AccessMulti-scale coupled attention for visual object detection
The application of deep neural network has achieved remarkable success in object detection. However, the network structures should be still evolved consistently and tuned finely to acquire better performance. ...
-
Article
AHC-Net: a road crack segmentation network based on dual attention mechanism and multi-feature fusion
To solve the problem of incomplete and inaccurate pavement crack detection, an improved U-Net model based on dual attention mechanism and multi-feature fusion is proposed. Firstly, a new encoding module ACI is...
