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131 Result(s)
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Open AccessTwo noncompeting human neutralizing antibodies targeting MPXV B6 show protective effects against orthopoxvirus infections
The recent outbreak of mpox epidemic, caused by monkeypox virus (MPXV), poses a new threat to global public health. Here, we initially assessed the preexisting antibody level to the MPXV B6 protein in vaccinia...
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Open AccessThe application of machine learning techniques in posttraumatic stress disorder: a systematic review and meta-analysis
Posttraumatic stress disorder (PTSD) recently becomes one of the most important mental health concerns. However, no previous study has comprehensively reviewed the application of big data and machine learning ...
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Open AccessAdvances in management of metabolic dysfunction-associated steatotic liver disease: from mechanisms to therapeutics
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the leading cause of chronic liver disease that affects over 30% of the world’s population. For decades, the heterogeneity of non-alcoholic f...
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Decitabine induces IRF7-mediated immune responses in p53-mutated triple-negative breast cancer: a clinical and translational study
p53 is mutated in half of cancer cases. However, no p53-targeting drugs have been approved. Here, we reposition decitabine for triple-negative breast cancer (TNBC), a subtype with frequent p53 mutations and ex...
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Hypertension combined with atherosclerosis increases the risk of heart failure in patients with diabetes
The increase in heart failure risk in the diabetic population when hypertension and atherosclerosis are both present is still inconclusive. The aim of this study was to explore the effects of hypertension comb...
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Open AccessPorphyromonas gingivalis aggravates colitis via a gut microbiota-linoleic acid metabolism-Th17/Treg cell balance axis
Periodontitis is closely related to inflammatory bowel disease (IBD). An excessive and non-self-limiting immune response to the dysbiotic microbiome characterizes the two. However, the underlying mechanisms th...
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Open AccessThoracic paravertebral block for perioperative lung preservation during VATS pulmonary surgery: study protocol of a randomized clinical trial
Postoperative pulmonary complications (PPCs) extend the length of stay of patients and increase the perioperative mortality rate after video-assisted thoracoscopic (VATS) pulmonary surgery. Thoracic paraverteb...
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Open AccessThe impact of isolation on comorbidity of PTSD symptoms and depression: evidence from PTRP-5-6 in China
The Omicron pandemic struck Shanghai, China, resulting in impairments of both physical and psychological health on those patients who were confirmed and transferred to the Fangcang shelters. The way of isolati...
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Open AccessA multi-model based on radiogenomics and deep learning techniques associated with histological grade and survival in clear cell renal cell carcinoma
This study aims to evaluate the efficacy of multi-model incorporated by radiomics, deep learning, and transcriptomics features for predicting pathological grade and survival in patients with clear cell renal c...
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Open AccessNitrogen-Doped Magnetic-Dielectric-Carbon Aerogel for High-Efficiency Electromagnetic Wave Absorption
An ingenious design achieved magnetic-dielectric-carbon coupling.
Nickel and manganese oxide particles were in situ reduced...
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Open AccessVH-CH1 switch region-inserting multispecific antibody designs and their efficacy against SARS-CoV-2 in vitro and in vivo
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Open AccessCausal relationships between blood lipids and major psychiatric disorders: Univariable and multivariable mendelian randomization analysis
Whether the positive associations of blood lipids with psychiatric disorders are causal is uncertain. We conducted this two-sample Mendelian randomization (MR) analysis to comprehensively investigate associati...
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A pan-coronavirus peptide inhibitor prevents SARS-CoV-2 infection in mice by intranasal delivery
Coronaviruses (CoVs) have brought serious threats to humans, particularly severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2), which continually evolves into multiple variants. These variants, especia...
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Open AccessElevated high-sensitivity C-reactive protein levels increase the risk of new-onset cardiac conduction disorders
Previous studies have reported that inflammatory responses can promote the onset of cardiovascular diseases; however, its association with cardiac conduction disorders remains unclear. The present community-ba...
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Ultralight, hierarchical metal–organic framework derivative/graphene hybrid aerogel for electromagnetic wave absorption
On the basis of high-efficiency electrostatic assembly, a type of ultralight, hydrophobic, hierarchically porous aerogels composed of metal–organic framework (MOF)-derived magnetic γ-Fe2O3@C/graphene are prepared...
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Open AccessEffects of probiotic administration on overweight or obese children: a meta-analysis and systematic review
This paper aimed to examine the effects of probiotics on eight factors in overweight or obese children by meta-analysis, namely, body mass index (BMI), total cholesterol (TC), triglyceride (TG), high-density l...
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Open AccessInvestigation and analysis of porcine epidemic diarrhea cases and evaluation of different immunization strategies in the large-scale swine farming system
Porcine epidemic diarrhea (PED) is a contagious intestinal disease caused by porcine epidemic diarrhea virus (PEDV) characterized by vomiting, diarrhea, anorexia, and dehydration, which has caused huge economi...
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A donor–acceptor-type hole-selective contact reducing non-radiative recombination losses in both subcells towards efficient all-perovskite tandems
The efficiency of all-perovskite tandem solar cells has surpassed that of single-junction perovskite solar cells, yet they still suffer from interfacial non-radiative recombination losses. Charge-selective mat...
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Open AccessKnockout of PERK protects rat Müller glial cells against OGD-induced endoplasmic reticulum stress-related apoptosis
The pathological basis for many retinal diseases, retinal ischemia is also one of the most common causes of visual impairment. Numerous ocular diseases have been linked to Endoplasmic reticulum(ER)stress. Howe...