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Article
Open AccessTrastuzumab-functionalized bionic pyrotinib liposomes for targeted therapy of HER2-positive breast cancer
In this study, we prepared a bionic nanosystem of trastuzumab-functionalized SK-BR-3 cell membrane hybrid liposome-coated pyrotinib (Ptb-M-Lip-Her) for the treatment of HER2-positive breast cancer. Transmissio...
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Article
Open AccessGenome-wide association analysis and transgenic characterization for amylose content regulating gene in tuber of Dioscorea zingiberensis
Amylose, a prebiotic found in yams is known to be beneficial for the gut microflora and is particularly advantageous for diabetic patients’ diet. However, the genetic machinery underlying amylose production re...
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Article
Meta-analysis of root-associated bacterial communities of widely distributed native and invasive Poaceae plants in Antarctica
Deschampsia antarctica Desv. and Poa annua L. are two Poaceae plants with enough endurance to successfully establish populations in the Antarctic region. Their adaptation to the Antarctic environment is closely l...
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Article
Open AccessExperiences of formal caregivers of elderly inpatients with physical disabilities in China: a qualitative study
To explore the views and experiences of formal caregivers caring for older inpatients with physical disabilities.
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Article
Bicyclol Alleviates Streptozotocin-induced Diabetic Cardiomyopathy By Inhibiting Chronic Inflammation And Oxidative Stress
Diabetic cardiomyopathy (DCM) is a common and severe complication of diabetes. Inflammation and oxidative stress play important roles in DCM development. Bicyclol is a hepatoprotective drug in China that exert...
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Article
Open AccessDeep Visual-guided and Deep Reinforcement Learning Algorithm Based for Multip-Peg-in-Hole Assembly Task of Power Distribution Live-line Operation Robot
The inspection and maintenance of power distribution network are crucial for efficiently delivering electricity to consumers. Due to the high voltage of power distribution network lines, manual live-line opera...
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Article
Open AccessBaicalin nanodelivery system based on functionalized metal-organic framework for targeted therapy of osteoarthritis by modulating macrophage polarization
Intra-articular drugs used to treat osteoarthritis (OA) often suffer from poor pharmacokinetics and stability. Nano-platforms as drug delivery systems for drug delivery are promising for OA therapy. In this st...
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Article
An aptamer-driven DNA nanodevice for improved delivery of synthetic immunostimulants
Efficient delivery of therapeutics to immune cells remains a formidable challenge for cancer immunotherapy. In this work, we demonstrate that an aptamer-driven DNA nanodevice, constructed through linkage of a ...
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Article
Open AccessDevelopment and validation of the hospice professional co** scale among Chinese nurses
Hospice care professionals often experience trauma patient deaths and multiple patient deaths in a short period of time (more so than other nurses). This repeated exposure to the death process and the death of...
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Article
Comparative performance and transcriptomics of tomato (Solanum lycopersicum) in response to Bombus terrestris (Hymenoptera, Apidae) and 2,4-dichlorophenoxyacetic acid
The introduction of pollinator bumblebees (Bombus terrestris) or using the plant hormone, 2,4-dichlorophenoxyacetic acid (2,4-D), are common methods to improve tomato production in greenhouses. In this study, we ...
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Article
Investigation of cellular communication and signaling pathways in tumor microenvironment for high TP53-expressing osteosarcoma cells through single-cell RNA sequencing
Osteosarcoma (OS) stands as the most prevalent primary bone cancer in children and adolescents, and its limited treatment options often result in unsatisfactory outcomes, particularly for metastatic cases. The...
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Article
Improving Microstructure and Corrosion Resistance of Cold Spraying Cu Coating Through Annealing
In order to improve the microstructure and corrosion resistance of the Cu coating prepared by low-pressure cold spraying, the Cu coating was annealed at different temperatures. The microstructure of Cu coating...
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Article
Open AccessPurification, structural characterization, and immunoregulatory activity of a polysaccharide from mulberry branch
In view of the fact that mulberry branch has not been effectively utilized and polysaccharide is one of the main active components in mulberry branch, this study aims to reveal the structure and immunomodulato...
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Article
A direct electrochemical sensor based on covalent organic frameworks/platinum nanoparticles for the detection of ofloxacin in water
A direct electrochemical sensor based on covalent organic frameworks (COFs)/platinum nanoparticles (PtNPs) composite was fabricated for the detection of ofloxacin (OFX) in water. Firstly, the COF material was...
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Article
Open AccessThe impact of kidney function on plasma neurofilament light and phospho-tau 181 in a community-based cohort: the Shanghai Aging Study
The blood-based biomarkers are approaching the clinical practice of Alzheimer’s disease (AD). Chronic kidney disease (CKD) has a potential confounding effect on peripheral protein levels. It is essential to ch...
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Article
Open AccessPopulation structure and adaptability analysis of Schizothorax o’connori based on whole-genome resequencing
Schizothorax o’connori is an endemic fish distributed in the upper and lower reaches of the Yarlung Zangbo River in China. It has experienced a fourth round of whole gene replication events and is a good model fo...
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Article
Interplay of IL-33 and IL-35 Modulates Th2/Th17 Responses in Cigarette Smoke Exposure HDM-Induced Asthma
Cigarette smoke (CS) facilitates adverse effects on the airway inflammation and treatment of asthma. Here, we investigated the mechanisms by which CS exacerbates asthma. The roles of IL-33 and IL-35 in asthma ...
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Article
Open AccessImmunogenic cell death-related classification reveals prognosis and effectiveness of immunotherapy in breast cancer
Lack of specific biomarkers and effective drug targets constrains therapeutic research in breast cancer (BC). In this regard, therapeutic modulation of damage-associated molecular patterns (DAMPs)-induced immu...
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Article
Open AccessCorrection: Control of two-spotted spider mite, Tetranychus urticae, on strawberry by integrating with cyetpyrafen and Phytoseiulus persimilis
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Chapter and Conference Paper
An H-Shape Magnetic Coupler of the WPT Systems for the Cervical Vertebral Fusion
The adjacent segment degeneration after cervical spine fusion can severely impact the surgical efficacy. Therefore, it is necessary to monitor the stress of the adjacent segments and prevent degenerative disea...
