6 Result(s)
within
Laura M. Garrick
English
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Article
Open AccessA direct comparison of divalent metal-ion transporter (DMT1) and hinokitiol, a potential small molecule replacement
Hinokitiol, a natural lipophilic chelator, appears capable of replacing several iron transporters after they have been genetically ablated. Divalent metal-ion transporter (DMT1) is the major iron importer in e...
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Article
Open AccessA role for divalent metal transporter (DMT1) in mitochondrial uptake of iron and manganese
Much of iron and manganese metabolism occurs in mitochondria. Uptake of redox-active iron must be tightly controlled, but little is known about how metal ions enter mitochondria. Recently, we established that ...
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Article
Isoform specific regulation of divalent metal (ion) transporter (DMT1) by proteasomal degradation
Divalent metal ion transporter (DMT1) is the major transporter for iron entrance into mammalian cells and iron exit from endosomes during the transferrin cycle. Four major mRNA isoforms correspond to four prot...
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Article
DMT1: A mammalian transporter for multiple metals
DMT1 has four names, transports as many as eight metals, may have four or more isoforms and carries out its transport for multiple purposes. This review is a start at sorting out these multiplicities. A G185R ...
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Chapter
Divalent metal transporter DMT1 (SLC11A2)
This chapter will discuss the properties of DMTl and its relationship to iron uptake and iron trafficking (and the metabolism of other metals as well); we will describe the existing mutants representing specif...
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Article
Testing with puromycin for amino acyl trnas that limit the rate of peptide chain extension
With puromycin one can recognize when the synthesis of a given protein is dependent on amino acyl tRNA that is present in rate limiting amount. We demonstrate this use of puromycin by its interaction with anot...
