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Chapter
Antitumor SOD Compounds
Many studies have been recently performed on the activity of the enzyme superoxide dismutase (SOD) in tumor cells. This enzyme catalyzes the reaction ...
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Article
Pharmacologic activities of copper compounds in chronic diseases
Copper complexes have been shown to be effective antiinflammatory, antiulcer, anticonvulsant, anticancer, and antidiabetic agents. This seemingly diverse variety of pharmacologic effects is unified by the hypo...
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Article
Anticancer activity of metal compounds with superoxide dismutase activity
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Article
Kidney glomerular explants in serum-free media: Demonstration of intracellular antioxidant enzymes and active oxygen metabolites
Guinea pig glomeruli were grown for 22 d in a serum-free medium composed of Waymouth's MB 752/1 supplemented with sodium pyruvate, nonessential amino acids, and antibiotics (the basic medium). Intracellular ce...
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Article
In vitro modulation of antioxidant enzymes in normal and malignant renal epithelium
The activities of three antioxidant enzymes, superoxide dismutase, catalase, and glutathione peroxidase, were monitored in isolated human renal adenocarcinoma tissues and in cultured human renal adenocarcinoma...
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Article
Role of antioxidant enzymes in cell immortalization and transformation
The role of antioxidant enzymes, particularly superoxide dismutase (SOD), in immortalization and malignant transformation is discussed. SOD (generally MnSOD) has been found to be lowered in a wide variety of t...
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Article
Immunolocalization of manganese superoxide dismutase in normal and transgenic mice expressing the human enzyme
The localization of manganese superoxide dismutase (MnSOD) was determined using immunohistochemistry of various tissues of normal and transgenic mice which express the human enzyme, with emphasis on studies of...
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Article
Immunolocalization of antioxidant enzymes in adult hamster kidney
Immunoperoxidase and immunogold techniques were used to localize the following antioxidant enzyme systems in the adult hamster kidney at the light and ultrastructural levels: superoxide dismutases, catalases, ...
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Article
Immunohistochemical localization of antioxidant enzymes during hamster kidney development
Immunolocalization studies of hamster kidney development were performed using polyclonal antibodies to antioxidant enzymes, including antibodies to copper, zinc and manganese superoxide dismutases, catalase, g...
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Article
Immunohistochemical localization of antioxidant enzymes during hamster kidney development
Immunolocalization studies of hamster kidney development were performed using polyclonal antibodies to antioxidant enzymes, including antibodies to copper, zinc and manganese superoxide dismutases, catalase, g...
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Article
Suppression of the malignant phenotype of human glioma cells by overexpression of manganese superoxide dismutase
Manganese superoxide dismutase (MnSOD) has been previously shown to suppress the malignant phenotype of human melanoma and breast cancer cells. To test the possible role of MnSOD in glioma malignancy, MnSOD wa...
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Article
Immunohistochemical characterization of antioxidant enzymes in human breast cancer
Intrinsic antioxidant enzymes (AE) are essential for protection against potential cellular damage by free radicals (FRs), which affect a variety of biological processes. The levels or activities of AEs can be ...
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Article
Inhibition of tumor cell growth by overexpression of manganese-containing superoxide dismutase
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Article
Overexpression of Glia Maturation Factor in C6 Cells Promotes Differentiation and Activates Superoxide Dismutase
In order to evaluate the intracellular function of glia maturation factor (GMF), we overexpressed GMF in C6 rat glioma cells using two methods: stable transfection using the pcDNA3 plasmid, and transient trans...
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Chapter
Eicosapentaenoic Acid Alters Manganese Superoxide Dismutase Immunoreactive Protein Levels in Normal But not Maligant Central Nervous System Derived Cells
The dose of radiation that safely can be administered to patients with malignant gliomas is limited by the potential for severe CNS morbidity. Manipulations that might increase the radiation sensitivity of gli...
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Article
Increased manganese superoxide dismutase (SOD-2) is part of the mechanism for prostate tumor suppression by Mac25/insulin-like growth factor binding-protein-related protein-1
Increased expression of mac25/insulin-like growth factor binding-protein related protein-1 (IGFBP-rP1) in human breast and prostate epithelial cell lines results in the suppression of tumor growth. CDNA expres...
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Article
Effect of expression of manganese superoxide dismutase in baculovirus-infected insect cells
It has previously been demonstrated that baculovirus infection of the Spodoptera frugiperda Sf-9 (Sf-9) and Trichoplusia ni BTI-Tn-5B1-4 (Tn-5B1-4) insect cell lines leads to oxidative stress as measured by prote...
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Article
Manganese superoxide dismutase overexpression inhibits the growth of androgen-independent prostate cancer cells
This study investigates the role of the antioxidant enzyme manganese superoxide dismutase (MnSOD) in androgen-independent human prostate cancer (PC-3) cells' growth rate in vitro and in vivo. MnSOD levels were fo...
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Article
Metastatic Progression of Pancreatic Cancer: Changes in Antioxidant Enzymes and Cell Growth
Pancreatic cancer has a dismal prognosis due to the fact that patients present late when metastatic disease is already present. Previous studies have demonstrated that pancreatic cancer cells have decreased le...
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Article
Manganese superoxide dismutase suppresses hypoxic induction of hypoxia-inducible factor-1α and vascular endothelial growth factor
Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that governs cellular responses to reduced O2 availability by mediating crucial homeostatic processes. HIF-1 is composed of an HIF-1α subunit and an HI...
