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Article
Angiogenèse: retour au fondamental
In the evolution of a cancer, tumorigenesis is the stage at which the initial molecular and cellular process develops a tissue dimension and, in particular, takes on a clinical aspect. This stage is made possi...
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Article
Hétérogénéité géographique de la prévalence de l’infection à HPV: résultats d’une étude au centre nord du Maroc
Au Maroc, le cancer du col de l’utérus demeure un véritable problème de santé publique au moment où son incidence diminue dans les pays développés. Cette diminution est liée au dépistage précoce qui se base su...
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Article
Relations du système plasminogène-plasmine et cancer
Proteases play a central role in tissue repair and in the process of tumour growth and invasiveness. However, almost all of the proteolytic enzymes are secreted as inactive pro-proteases. With the exception of...
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Article
Stroma : partenaire actif mais sous-estiméde la tumorigenèse, « quand le dialogue remplace le monologue »
In the evolution of a cancer, tumorigenesis is the stage at which the initial molecular and cellular process develops a tissue dimension and, in particular, takes on a clinical aspect. This stage is made possi...
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Chapter
Interactions entre les cellules tumorales et le microenvironnement tissulaire : « Quand le dialogue remplace le monologue »
Dès 1970, le cancer du sein a été une des premières pathologies tumorales à bénéficier d’une approche analytique biologique à application clinique promue par le groupe du Pr W.L. McGuire. Le plan cancer décidé...
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Article
Identification of secondary structure in the 5′-untranslated region of the human adrenomedullin mRNA with implications for the regulation of mRNA translation
Adrenomedullin (AM) is a multifunctional regulatory peptide with important angiogenic and mitogenic properties. Here we identify a region of stable secondary structure in the 5′-untranslated region (5′ UTR) of...
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Article
Open AccessFrequency and genome load of Epstein-Barr virus in 509 breast cancers from different geographical areas
Since the few data exploring a possible association between Epstein–Barr virus (EBV) and breast cancer are conflicting, we investigated this association together with the influences of geographical areas. 509 ...
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Chapter
Thyrotropin Releasing Hormone in Neonatal Rat Pancreas Regulation of Biosynthesis and Secretion
TRH immunoreactivity in the neonate rat pancreas peaks at day 4 after birth. TRH mRNA profile parallels and preceeds by 48 hrs that of TRH immunoreactive material.
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Ontogenetic Development of TRH-Degrading Enzymes and TRH-Metabolites in the Rat Pancreas
The ontogenetic patterns of thyrotropin-releasing hormone (TRH)-degrading enzymes and endogenous immunoreactive TRH, diketopiperazine (DKP) and TRH free acid (TRH-OH) have been studied in neonatal rat pancreas. D...