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Article
Open AccessThe effect of bariatric surgery type on cardiac reverse remodelling
Bariatric surgery is effective in reversing adverse cardiac remodelling in obesity. However, it is unclear whether the three commonly performed operations; Roux-en-Y Gastric Bypass (RYGB), Laparoscopic Sleeve ...
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Article
Open AccessEffect of empagliflozin on ectopic fat stores and myocardial energetics in type 2 diabetes: the EMPACEF study
Empagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor that has demonstrated cardiovascular and renal protection in patients with type 2 diabetes (T2D). We hypothesized that empaglifozin (EMPA) co...
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Article
Pioglitazone in adult rats reverses immediate postnatal overfeeding-induced metabolic, hormonal, and inflammatory alterations
Immediate postnatal overfeeding in rats, obtained by reducing the litter size, results in early-onset obesity. Such experimental paradigm programs overweight, insulin resistance, dyslipidemia, increased adipos...
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Article
Open AccessComparison of the gut microbiota of people in France and Saudi Arabia
The gut microbiota contributes to energy acquisition from food, and changes in the gut microbiome are associated with obesity. The eating habits of Saudis are much different than those of Europeans, and our ob...
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Article
Ectopic fat storage in the pancreas using 1H-MRS: importance of diabetic status and modulation with bariatric surgery-induced weight loss
Recent literature suggests that ectopic fat deposition in the pancreas may contribute to endocrine and exocrine organ dysfunction, such as type 2 diabetes (T2D), pancreatitis or pancreatic cancer. The aim of t...
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Article
Assessment of epicardial fat volume and myocardial triglyceride content in severely obese subjects: relationship to metabolic profile, cardiac function and visceral fat
To assess epicardial fat volume (EFV), myocardial TG content (MTGC) and metabolic profile in severely obese patients, and to determine whether ectopic fat depots are linked to metabolic disorders or myocardial...
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Article
Myelofibrosis: an unusual presentation of vitamin D-deficient rickets
We present the case of a breast-fed 5-month-old infant who presented with pancytopenia, secondary to intense myelofibrosis during the winter months because of undiagnosed rickets. The patient responded to ora...
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Article
Relationship between hypophyseal portal GHRH and somatostatin and peripheral GH levels in the conscious sheep
The mechanisms involved in the genesis of pulsatile GH secretion are not well understood. Recently, methods for hypophyseal portal blood collection in conscious sheep became available. Using this method, GHRH ...
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Chapter
Circulating Blood Glucose and Hypothalamic-Pituitary Secretion
Normally glucose accounts for more than 90% of the metabolic fuel of the brain (1). A constant supply and utilization of glucose is essential for normal cerebral metabolism since brain carbohydrate stores are ...
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Chapter
Differences in the Effects of Acute and Chronic Administration of Dexfenfluramine on Cortisol and Prolactin Secretion
The involvement of serotonin on neuroendocrine regulation has been substantiated by much experimental data. Indeed, serotonin has been shown to play a role in the regulation of pituitary hormones that display ...
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Chapter
Thyrotropin Releasing Hormone in Neonatal Rat Pancreas Regulation of Biosynthesis and Secretion
TRH immunoreactivity in the neonate rat pancreas peaks at day 4 after birth. TRH mRNA profile parallels and preceeds by 48 hrs that of TRH immunoreactive material.
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Chapter
Ontogenetic Development of TRH-Degrading Enzymes and TRH-Metabolites in the Rat Pancreas
The ontogenetic patterns of thyrotropin-releasing hormone (TRH)-degrading enzymes and endogenous immunoreactive TRH, diketopiperazine (DKP) and TRH free acid (TRH-OH) have been studied in neonatal rat pancreas. D...