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  1. No Access

    Article

    Glutamic Acid Signal Synchronizes Protein Synthesis Kinetics in Hepatocytes from Old Rats for the Following Several Days. Cell Metabolism Memory

    The kinetics of protein synthesis was investigated in primary cultures of hepatocytes from old rats in serum–free medium. The rats were fed mixed fodder supplemented with glutamic acid and then transferred to ...

    V. Y. Brodsky, L. A. Malchenko, D. S. Lazarev, N. N. Butorina… in Biochemistry (Moscow) (2018)

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    Article

    Glutamic acid as enhancer of protein synthesis kinetics in hepatocytes from old rats

    Dense cultures of hepatocytes from old rats (~2 years old, body weight 530-610 g) are different from similar cultures of hepatocytes from young rats by the low amplitude of protein synthesis rhythm. Addition o...

    V. Y. Brodsky, L. A. Malchenko, N. N. Butorina… in Biochemistry (Moscow) (2017)

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    Article

    Glutamic acid – amino acid, neurotransmitter, and drug – is responsible for protein synthesis rhythm in hepatocyte populations in vitro and in vivo

    Primary cultures of rat hepatocytes were studied in serum-free media. Ultradian protein synthesis rhythm was used as a marker of cell synchronization in the population. Addition of glutamic acid (0.2 mg/ml) to...

    V. Y. Brodsky, L. A. Malchenko, D. S. Konchenko, N. D. Zvezdina… in Biochemistry (Moscow) (2016)