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Article
Microneedle systems for delivering nucleic acid drugs
Nucleic acid-based gene therapy is a promising technology that has been used in various applications such as novel vaccination platforms for infectious/cancer diseases and cellular reprogramming because of its...
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Article
mRNA vaccines: the most recent clinical applications of synthetic mRNA
Synthetic mRNA has been considered as an emerging biotherapeutic agent for the past decades. Recently, the SARS-CoV-2 pandemic has led to the first clinical use of synthetic mRNA. mRNA vaccines showed far surp...
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Article
Cellular Delivery of siRNA Using Poly(2-dimethylaminoethyl methacrylate)- Functionalized Graphene Oxide Nano-Wrap
Despite its high therapeutic potential, the use of siRNA has still been limited mostly due to the lack of a proper delivery system. Small number of charges and inflexible structure of siRNA are the major facto...
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Article
Development of mRNA vaccines and their prophylactic and therapeutic applications
Nucleic acid vaccines have attracted enormous attention for resolving the limitations of conventional vaccines using live attenuated viruses. Because nucleic acid vaccines can be produced rapidly in response t...
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Article
The cutting-edge technologies of siRNA delivery and their application in clinical trials
siRNA therapeutics allows precise regulation of disease specific gene expression to treat various diseases. Although gene silencing approaches using siRNA therapeutics shows some promising results in the treat...
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Article
Significance and strategies in develo** delivery systems for bio-macromolecular drugs
Successful development of a new drug is prohibitively expensive, and is estimated to cost approximately $100—500 million US dollars for a single clinical drug. Yet, a newly developed drug can only enjoy its pa...
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Article
Magnetic Nanoparticles for Tumor Imaging and Therapy: A So-Called Theranostic System
In this review, we discussed the establishment of a so-called “theranostic” system by instituting the basic principles including the use of: [1] magnetic iron oxide nanoparticles (MION)-based drug carrier; [2]...
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Article
Enhanced Transfection by Antioxidative Polymeric Gene Carrier that Reduces Polyplex-Mediated Cellular Oxidative Stress
To test the hypothesis in which polyplex-induced oxidative stress may affect overall transfection efficiency, an antioxidative transfection system minimizing cellular oxidative stress was designed for enhanced...
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Article
Controlled Release of Simvastatin from In situ Forming Hydrogel Triggers Bone Formation in MC3T3-E1 Cells
Simvastatin (SIM), a drug commonly administered for the treatment of hypercholesterolemia, has been recently reported to induce bone regeneration/formation. In this study, we investigated the properties of hyd...
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Article
Polyethylenimine-g-poly(lactic-co-glycolic acid) as non-toxic micelle-type carrier for gene delivery
Branched polyethylenimine (bPEI) has long been considered as a gold standard for non-viral gene transfection owing to its excellent gene condensing property and consistent transfection efficiency in various ce...
