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Article
Understanding the Molecular Regulation of Serotonin Receptor 5-HTR1B-β-Arrestin1 Complex in Stress and Anxiety Disorders
The serotonin receptor subtype 5-HTR1B is widely distributed in the brain with an important role in various behavioral implications including neurological conditions and psychiatric disorders. The neuromodulatory...
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Article
miRNA regulation of G protein-coupled receptor mediated angiogenic pathways in cancer
Angiogenesis is an important biological process associated with plethora of physiological and patho-physiological conditions. Recent data suggests that fine balance between anti-angiogenic microRNA (miRNA) and...
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Article
A complex structure of arrestin-2 bound to a G protein-coupled receptor
Arrestins comprise a family of signal regulators of G-protein-coupled receptors (GPCRs), which include arrestins 1 to 4. While arrestins 1 and 4 are visual arrestins dedicated to rhodopsin, arrestins 2 and 3 (...
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Article
Open AccessMolecular assembly of rhodopsin with G protein-coupled receptor kinases
G protein-coupled receptor kinases (GRKs) play pivotal roles in desensitizing GPCR signaling but little is known about how GRKs recognize and phosphorylate GPCRs due to the technical difficulties in detecting ...