18 Result(s)
within
Kuan Teh JEANG
Life Sciences
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Article
Open AccessRing finger protein 39 genetic variants associate with HIV-1 plasma viral loads and its replication in cell culture
The human immunodeficiency virus (HIV-1) exploits host proteins to complete its life cycle. Genome-wide siRNA approaches suggested that host proteins affect HIV-1 replication. However, the results barely overl...
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Article
Open AccessSorting nexin 24 genetic variation associates with coronary artery aneurysm severity in Kawasaki disease patients
The sorting nexin (SNX) family is involved in endocytosis and protein trafficking and plays multiple roles in various diseases. The role of SNX proteins in Kawasaki disease (KD) is not known. We attempted to t...
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Article
Open AccessTombusvirus P19 RNA silencing suppressor (RSS) activity in mammalian cells correlates with charged amino acids that contribute to direct RNA-binding
Tombusvirus P19 is a protein encoded by tomato bushy stunt virus and related tombusviruses. Earlier studies have demonstrated that P19 is an RNA silencing suppressor (RSS) in plant cells. However, it has not b...
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Article
Open AccessA measure of success
Cell and Bioscience is on track to receive its first Impact Factor in mid-2013. What is the role of the Impact Factor as a measure of a journal’s success?
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Article
Open AccessRNAi in the regulation of mammalian viral infections
Although RNA interference (RNAi) is known to play an important part in defense against viruses of invertebrates, its contribution to mammalian anti-viral defense has been a matter of dispute. This is surprisin...
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Article
Open AccessUnstabilized DNA breaks in HTLV-1 Tax expressing cells correlate with functional targeting of Ku80, not PKcs, XRCC4, or H2AX
Expression of the human T-cell leukemia virus type 1 (HTLV-1) Tax oncoprotein rapidily induces a significant increase of micronuclei (MN) and unstabilized DNA breaks in cells. Unstabilized DNA breaks can have ...
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Article
Open AccessEpidermal growth factor receptor (EGFR) biology and Wnt developmental signaling highlight research endeavors of SCBA award winners
This months Cell and Bioscience highlights review articles by Mien-Chie Hung on EGFR biology and Yingzi Yang on Wnt signaling. Dr. Hung was the 2011 Society of Chinese Bioscientists in America (SCBA) Presidential...
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Open AccessReplication competent HIV-1 viruses that express intragenomic microRNA reveal discrete RNA-interference mechanisms that affect viral replication
It remains unclear whether retroviruses can encode and express an intragenomic microRNA (miRNA). Some have suggested that processing by the Drosha and Dicer enzymes might preclude the viability of a replicatin...
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Open AccessA proteomic study of TAR-RNA binding protein (TRBP)-associated factors
The human TAR RNA-binding protein, TRBP, was first identified and cloned based on its high affinity binding to the small hairpin trans-activation responsive (TAR) RNA of HIV-1. TRBP has more recently been foun...
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Open AccessIf you organize, they will join
This Editorial briefly introduces the Society of Chinese Bioscientists in America (SCBA) to readers of Cell & Bioscience.
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Protocol
A Method to Study the Role of DDX3 RNA Helicase in HIV-1
Viral replication requires the use of host cell proteins and enzymes. Many viruses utilize viral helicases at various stages of their life cycle; these viruses have evolved to encode directly helicase or helic...
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Article
The retroviral oncoprotein Tax targets the coiled-coil centrosomal protein TAX1BP2 to induce centrosome overduplication
Emerging evidence suggests that supernumerary centrosomes drive genome instability and oncogenesis1,2,3. Human T-cell leukaemia virus type I (HTLV-I) is etiologically associated with adult T-cell leukaemia (ATL)4
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Protocol
MicroRNAs in Human Immunodeficiency Virus-1 Infection
Initially reported for Caenorhabditis elegans, microRNA (miRNA) has been shown to regulate gene expression in plants, flies, and mammals (1,2). Recently, findings of miRNA have been extended to viruses (3,4). Her...
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Article
siRNA, miRNA and HIV: promises and challenges
Small interfering RNA (siRNA) and microRNA (miRNA) are small RNAs of 18-25 nucleotides (nt) in length that play important roles in regulating gene expression. They are incorporated into an RNA-induced silencin...
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Article
A non-proteolytic role for ubiquitin in Tat-mediated transactivation of the HIV-1 promoter
The human immunodeficiency virus type 1 (HIV-1) encodes a potent transactivator, Tat, which functions through binding to a short leader RNA, called transactivation responsive element (TAR). Recent studies sugg...
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Chapter
HTLV-I Tax and cell cycle progression
Human T-cell leukemia virus type I (HTLV-I) is the etiological agent for adult T-cell leukemia (ATL) and various human myopathies/neuropathies. HTLV-I encodes a 40 kDa phosphoprotein, Tax, which has been impli...
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Article
Genetic map** of six mouse peroxiredoxin genes and fourteen peroxiredoxin related sequences
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Chapter
HIV-1 Tat: A Transcriptional Activator that Recognizes a Structured RNA Target
The human and simian immunodeficiency viruses (HIVs and SIVs) are unique among retroviruses in encoding for many small regulatory proteins in addition to Gag, Pol and Env (reviewed in 1). Although counterpart ...
