Viruses and Human Cancer
From Basic Science to Clinical Prevention
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Reference Work Entry In depth
PIMT/TGS1
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Reference Work Entry In depth
Mitotic Arrest-Deficient Protein 1
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Living Reference Work Entry In depth
Mitotic Arrest-Deficient Protein 1
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Article
Open AccessRing finger protein 39 genetic variants associate with HIV-1 plasma viral loads and its replication in cell culture
The human immunodeficiency virus (HIV-1) exploits host proteins to complete its life cycle. Genome-wide siRNA approaches suggested that host proteins affect HIV-1 replication. However, the results barely overl...
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Article
Open AccessA novel HSP90 inhibitor, 17-DMAG, induces Tax down-regulation and its oral administration to ATL-model mice intervenes against the infiltration property of the ATL-like lymphocytes and provides extended survival period
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Quantification of miRNA by Poly(A)-RT-qPCR Arrays and Verification of Target Sites in HIV-1 Using a One-LTR Infectious Molecular Clone
Quantitative PCR (qPCR) provides a robust method for quantifying DNA species. By combining modern qPCR techniques with the isolation of small RNA, the polyadenylation of the RNA, and the use of reverse transcr...
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HTLV-1 and Leukemogenesis: Virus–Cell Interactions in the Development of Adult T-Cell Leukemia
Human T-cell lymphotropic virus type 1 (HTLV-1) was originally discovered in the early 1980s. It is the first retrovirus to be unambiguously linked causally to a human cancer. HTLV-1 currently infects approxi...
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Article
Open AccessSorting nexin 24 genetic variation associates with coronary artery aneurysm severity in Kawasaki disease patients
The sorting nexin (SNX) family is involved in endocytosis and protein trafficking and plays multiple roles in various diseases. The role of SNX proteins in Kawasaki disease (KD) is not known. We attempted to t...
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Open AccessReviewer acknowledgement 2012
Retrovirology would like to thank the following for their assistance with peer review of manuscripts for the journal in 2012.
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Living Reference Work Entry In depth
PIMT/TGS1
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Article
Open AccessWip1 and p53 contribute to HTLV-1 Tax-induced tumorigenesis
Human T-cell Leukemia Virus type 1 (HTLV-1) infects 20 million individuals world-wide and causes Adult T-cell Leukemia/Lymphoma (ATLL), a highly aggressive T-cell cancer. ATLL is refractory to treatment with c...
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Article
Open AccessHost restriction factors in retroviral infection: promises in virus-host interaction
Retroviruses have an intricate life cycle. There is much to be learned from studying retrovirus-host interactions. Among retroviruses, the primate lentiviruses have one of the more complex genome structures wi...
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Open AccessDiversity matters in scientific publishing
The importance of geographic diversity in publishing is emphasized in this editorial.
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Open AccessThe importance of ubiquitination and sumoylation on the transforming activity of HTLV Tax-1 and Tax-2
Human T-cell Leukemia Virus type 1 (HTLV-1) and 2 (HTLV-2) are two closely related human retroviruses. HTLV-1 is associated with an aggressive Adult T-cell Leukemia (ATL) while there is no evidence for an asso...
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Open AccessTombusvirus P19 RNA silencing suppressor (RSS) activity in mammalian cells correlates with charged amino acids that contribute to direct RNA-binding
Tombusvirus P19 is a protein encoded by tomato bushy stunt virus and related tombusviruses. Earlier studies have demonstrated that P19 is an RNA silencing suppressor (RSS) in plant cells. However, it has not b...
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Open AccessHighlights, predictions, and changes
Recent literature highlights at Retrovirology are described. Predictions are made regarding “hot” retrovirology research trends for the coming year based on recent journal access statistics. Changes in Retrovirol...
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Article
Open AccessImpact of cellular autophagy on viruses: Insights from hepatitis B virus and human retroviruses
Autophagy is a protein degradative process important for normal cellular metabolism. It is apparently used also by cells to eliminate invading pathogens. Interestingly, many pathogens have learned to subvert t...
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Article
Open AccessA measure of success
Cell and Bioscience is on track to receive its first Impact Factor in mid-2013. What is the role of the Impact Factor as a measure of a journal’s success?
