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Protocol
Give and Take: The Reciprocal Control of Metabolism and Cell Cycle
Cell cycle is an ordered sequence of events that occur in a cell preparing for cell division. The cell cycle is a four-stage p...
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Article
Open AccessRIP140 inhibits glycolysis-dependent proliferation of breast cancer cells by regulating GLUT3 expression through transcriptional crosstalk between hypoxia induced factor and p53
Glycolysis is essential to support cancer cell proliferation, even in the presence of oxygen. The transcriptional co-regulator RIP140 represses the activity of transcription factors that drive cell proliferati...
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Article
Open AccessThe multifunctional protein E4F1 links P53 to lipid metabolism in adipocytes
Growing evidence supports the importance of the p53 tumor suppressor in metabolism but the mechanisms underlying p53-mediated control of metabolism remain poorly understood. Here, we identify the multifunction...
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Article
TAG-RNAi overcomes off-target effects in cancer models
RNA interference offers therapeutic opportunities for the clinical targeting of otherwise undruggable oncogenes. However RNAi can have off-target effects that considerably increase treatment risks. To manage t...
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Article
MDM2 controls gene expression independently of p53 in both normal and cancer cells
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Article
Intrinsic ubiquitination activity of PCAF controls the stability of the oncoprotein Hdm2
The p300–CBP-associated factor (PCAF) is a histone acetyltransferase (HAT) involved in the reversible acetylation of various transcriptional regulators1, including the tumour suppressor p53. It is implicated in m...
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Article
A non-proteolytic role for ubiquitin in Tat-mediated transactivation of the HIV-1 promoter
The human immunodeficiency virus type 1 (HIV-1) encodes a potent transactivator, Tat, which functions through binding to a short leader RNA, called transactivation responsive element (TAR). Recent studies sugg...
