25 Result(s)

Article

Amitriptyline inhibits bronchoconstriction and directly promotes dilatation of the airways

The standard therapy for bronchial asthma consists of combinations of acute (short-acting ß₂-sympathomimetics) and, depending on the severity of disease, additional long-term treatment (including inhaled glucocor...

Paulina Hempel, Virag Klein, Anna Michely, Svenja Böll… in Respiratory Research (2023)

Article

Treat-to-target strategies for the management of familial Mediterranean Fever in children

The objective of this initiative was to develop a treat-to-target (T2T) approach for the management of patients with Familial Mediterranean Fever (FMF), including the definition of a complex treatment target, ...

Lisa Ehlers, Elisabeth Rolfes, Mareike Lieber, Dominik Müller… in Pediatric Rheumatology (2023)

Article

Tofacitinib fails to prevent T cell transfer colitis in mice but ameliorates disease activity

Tofactinib is a JAK inhibitor approved for ulcerative colitis in humans. Despite of its’ proven effectiveness in humans, mechanistic data are scarce on the effectiveness of Tofactinib in experimental colitis i...

Sudheendra Hebbar Subramanyam, Judit Turyne Hriczko, Angeliki Pappas… in Scientific Reports (2023)

Article

Outcome of adult patients with JIA treated with the biosimilar Benepali^®: results of the biologic register JuMBO

To analyze therapy adherence, safety, and outcome in adult patients with juvenile idiopathic arthritis (JIA) treated with the etanercept biosimilar Benepali^® (Biogen Inc, Cambridge, USA).

Kristina Vollbach, Klaus Tenbrock, Nobert Wagner… in Arthritis Research & Therapy (2022)

Article

Dysregulated neutrophilic cell death in SLE: a spotlight on ferroptosis

Kim Ohl, Thomas Rauen, Klaus Tenbrock in Signal Transduction and Targeted Therapy (2021)

Article

Experiences with IL-1 blockade in systemic juvenile idiopathic arthritis – data from the German AID-registry

Systemic juvenile idiopathic arthritis (sJIA) is a complex disease with dysregulation of the innate immune system driven by cytokines. A major role is ascribed to interleukin-1β (IL-1β), supporting the autoinf...

Elke Lainka, Melanie Baehr, Bernadette Raszka… in Pediatric Rheumatology (2021)

Article

Impaired functional capacity of polarised neonatal macrophages

Neonatal sepsis is accompanied by impaired apoptotic depletion of monocytes and macrophages (MΦ), aberrant cytokine production, impaired cell metabolism, and sustained inflammation. Macrophage-colony stimulati...

Stephan Dreschers, Kim Ohl, Nora Schulte, Klaus Tenbrock… in Scientific Reports (2020)

Article

Impaired cellular energy metabolism in cord blood macrophages contributes to abortive response toward inflammatory threats

Neonatal sepsis is characterized by hyperinflammation causing enhanced morbidity and mortality compared to adults. This suggests differences in the response towards invading threats. Here we investigate activa...

Stephan Dreschers, Kim Ohl, Michael Lehrke, Julia Möllmann… in Nature Communications (2019)

Article

Initiation of LPS-induced pulmonary dysfunction and its recovery occur independent of T cells

The acute respiratory distress syndrome (ARDS) is a serious disease in critically ill patients that is characterized by pulmonary dysfunctions, hypoxemia and significant mortality. Patients with immunodeficien...

Eva Verjans, Stephanie Kanzler, Kim Ohl, Annette D. Rieg… in BMC Pulmonary Medicine (2018)

Article

The transcription factor CREM drives an inflammatory phenotype of T cells in oligoarticular juvenile idiopathic arthritis

Inflammatory effector T cells trigger inflammation despite increased numbers of Treg cells in the synovial joint of patients suffering from juvenile idiopathic arthritis (JIA). The cAMP response element (CREM)...

Kim Ohl, Helge Nickel, Halima Moncrieffe, Patricia Klemm… in Pediatric Rheumatology (2018)

Article

Transcription factor motif enrichment in whole transcriptome analysis identifies STAT4 and BCL6 as the most prominent binding motif in systemic juvenile idiopathic arthritis

The term systemic juvenile idiopathic arthritis (sJIA) describes an autoinflammatory condition characterized by arthritis and severe systemic inflammation, which in later stages can transform into interleukin ...

Boris Hügle, Anastasia Schippers, Nadine Fischer, Kim Ohl… in Arthritis Research & Therapy (2018)

Article

Proceedings of the 23^rd Paediatric Rheumatology European Society Congress: part two

Olga Lomakina, Ekaterina Alekseeva, Sania Valieva… in Pediatric Rheumatology (2017)

Article

ICER is requisite for Th17 differentiation

Inducible cAMP early repressor (ICER) has been described as a transcriptional repressor isoform of the cAMP response element modulator (CREM). Here we report that ICER is predominantly expressed in Th17 cells ...

Nobuya Yoshida, Denis Comte, Masayuki Mizui, Kotaro Otomo… in Nature Communications (2016)

Article

No association of IL-12p40 pro1.1 polymorphism with juvenile idiopathic arthritis

IL-12p40 plays an important role in the activation of the T-cell lines like Th17 and Th1-cells. Theses cells are crucial in the pathogenesis of juvenile idiopathic arthritis. A polymorphism in its promoter reg...

Christiane S. Eberhardt, Johannes-Peter Haas, Hermann Girschick… in Pediatric Rheumatology (2015)

Article

The transcription factor crem-αlpha regulates inflammatory T cell subsets in juvenile idiopathic arthritis

Kim Ohl, Helge Nickel, Halima Moncrieffe, Lucy R Wedderburn… in Pediatric Rheumatology (2014)