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Article
Open AccessThe Treasury of Wharton's Jelly
Postnatal umbilical cord tissue contains valuable mesenchymal progenitor cells of various differentiation stages. While mesenchymal stem cells are plastic-adherent and tend to differentiate into myofibroblasti...
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Article
Open AccessImpaired functional capacity of polarised neonatal macrophages
Neonatal sepsis is accompanied by impaired apoptotic depletion of monocytes and macrophages (MΦ), aberrant cytokine production, impaired cell metabolism, and sustained inflammation. Macrophage-colony stimulati...
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Article
Open AccessImpaired cellular energy metabolism in cord blood macrophages contributes to abortive response toward inflammatory threats
Neonatal sepsis is characterized by hyperinflammation causing enhanced morbidity and mortality compared to adults. This suggests differences in the response towards invading threats. Here we investigate activa...
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Article
The CD95/CD95L pathway is involved in phagocytosis-induced cell death of monocytes and may account for sustained inflammation in neonates
The propensity for sustained inflammation after bacterial infection in neonates, resulting in inflammatory sequelae such as bronchopulmonary dysplasia and periventricular leucomalacia, is well known, but its m...
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Article
Ceramide, membrane rafts and infections
Distinct domains in the cell membrane, termed rafts, emerge as central for the infection of mammalian cells by many pathogens. Rafts consist of sphingolipids and cholesterol that interact strongly, and thus sp...
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Article
The Ets 1 transcription factor is upregulated during inflammatory angiogenesis in rheumatoid arthritis
Neovascularization of the inflamed synovium and pannus is one of the hallmarks of chronic rheumatoid arthritis. It contributes to disease progression by supplying blood to the inflamed tissues and by recruitin...
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Article
DPC4/SMAD4 mediated tumor suppression of colon carcinoma cells is associated with reduced urokinase expression
We recently identified DPC4/Smad4 as a candidate tumor suppressor gene mutated or lost in one half of pancreatic carcinomas and in a subset of colon and biliary tract carcinomas. DPC4 plays a key role in signal t...
