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Article
Open AccessTranscriptional regulation by normal epithelium of premalignant to malignant progression in Barrett’s esophagus
In carcinogenesis, intercellular interactions within and between cell types are critical but remain poorly understood. We present a study on intercellular interactions between normal and premalignant epithelia...
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Article
Open AccessVorinostat differentially alters 3D nuclear structure of cancer and non-cancerous esophageal cells
The histone deacetylase (HDAC) inhibitor vorinostat has received significant attention in recent years as an ‘epigenetic’ drug used to treat solid tumors. However, its mechanisms of action are not entirely und...
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Article
Open AccessTargeting polo-like kinase 1, a regulator of p53, in the treatment of adrenocortical carcinoma
Adrenocortical carcinoma (ACC) is an aggressive cancer with a 5 year survival rate of 20–30 %. Various factors have been implicated in the pathogenesis of ACC including dysregulation of the G2/M transition and...
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Article
Whole-genome Sequencing of an Aggressive BRAF Wild-type Papillary Thyroid Cancer Identified EML4–ALK Translocation as a Therapeutic Target
Recent advances in the treatment of cancer have focused on targeting genomic aberrations with selective therapeutic agents. In radioiodine resistant aggressive papillary thyroid cancers, there remain few effec...
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Article
Targeted Therapies for Adrenocortical Carcinoma: IGF and Beyond
Standard chemotherapy for adrenocortical cancer currently is under evaluation in the context of the recently completed FIRM-ACT evaluating the combination of mitotane with either streptozocin or etoposide, cis...
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Article
Open AccessMistaken Identifiers: Gene name errors can be introduced inadvertently when using Excel in bioinformatics
When processing microarray data sets, we recently noticed that some gene names were being changed inadvertently to non-gene names.
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Article
Comparing cDNA and oligonucleotide array data: concordance of gene expression across platforms for the NCI-60 cancer cells
Microarray gene-expression profiles are generally validated one gene at a time by real-time RT-PCR. We describe here a different approach based on simultaneous mutual validation of large numbers of genes using...
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Article
Open AccessMatchMiner: a tool for batch navigation among gene and gene product identifiers
MatchMiner is a freely available program package for batch navigation among gene and gene product identifier types commonly encountered in microarray studies and other forms of 'omic' research. The user inputs...
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Article
Open AccessGoMiner: a resource for biological interpretation of genomic and proteomic data
We have developed GoMiner, a program package that organizes lists of 'interesting' genes (for example, under- and overexpressed genes from a microarray experiment) for biological interpretation in the context ...
