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Open AccessCapicua (CIC) mutations in gliomas in association with MAPK activation for exposing a potential therapeutic target
Gliomas are the most prevalent neurological cancer in the USA and care modalities are not able to effectively combat these aggressive malignancies. Identifying new, more effective treatments require a deep und...
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The Role of Precision Medicine in the Diagnosis and Treatment of Patients with Rare Cancers
Rare cancers pose unique challenges for patients and their physicians arising from a lack of information regarding the best therapeutic options. Very often, a lack of clinical trial data leads physicians to ch...
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Precision Medicine: Disruptive Technology in the Modern Hospital
Precision medicine is coming. The application of genomic technologies to the diagnosis and treatment of diseases is becoming a reality for virtually every field of medicine. The promise is better outcomes for ...
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Open AccessTargeting polo-like kinase 1, a regulator of p53, in the treatment of adrenocortical carcinoma
Adrenocortical carcinoma (ACC) is an aggressive cancer with a 5 year survival rate of 20–30 %. Various factors have been implicated in the pathogenesis of ACC including dysregulation of the G2/M transition and...
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Whole-genome Sequencing of an Aggressive BRAF Wild-type Papillary Thyroid Cancer Identified EML4–ALK Translocation as a Therapeutic Target
Recent advances in the treatment of cancer have focused on targeting genomic aberrations with selective therapeutic agents. In radioiodine resistant aggressive papillary thyroid cancers, there remain few effec...
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Open AccessIdentification of somatic mutations in cancer through Bayesian-based analysis of sequenced genome pairs
The field of cancer genomics has rapidly adopted next-generation sequencing (NGS) in order to study and characterize malignant tumors with unprecedented resolution. In particular for cancer, one is often tryin...
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Open AccessCancer of the ampulla of Vater: analysis of the whole genome sequence exposes a potential therapeutic vulnerability
Recent advances in the treatment of cancer have focused on targeting genomicaberrations with selective therapeutic agents. In rare tumors, where large-scaleclinical trials are daunting, this targeted genomic a...
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Targeted Therapies for Adrenocortical Carcinoma: IGF and Beyond
Standard chemotherapy for adrenocortical cancer currently is under evaluation in the context of the recently completed FIRM-ACT evaluating the combination of mitotane with either streptozocin or etoposide, cis...
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Does laparoscopic adrenalectomy have a role in suspected ACC?
The recommended treatment for adrenocortical cancer (ACC) is surgical excision. Two studies have compared open versus laparoscopic adrenalectomy for tumor excision in patients with ACC, and have drawn differen...
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Reference Work Entry In depth
Surgical Considerations in the Elderly
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Article
Patient-based Surgical Outcome Tool Demonstrating Alleviation of Symptoms following Parathyroidectomy in Patients with Primary Hyperparathyroidism
This study assessed the impact of parathyroidectomy on the preoperative symptoms of patients with primary hyperparathyroidism (1° HPT) using a surgical outcome tool designed specifically for HPT. The multicen...
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Article
Subtotal Parathyroidectomy in Renal Failure: Still Needed after All These Years
There are scant data on the frequency of parathyroidectomy (PTX) for end-stage renal disease (ESRD). Medical therapy for ESRD and secondary hyperparathyroidism has evolved to include better dialytic urea remo...
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Article
Gip-2 Codon 179 Oncogene Mutations: Absent in Adrenal Cortical Tumors
p < 0.05, Fishers’ exact) previously reported but agrees with the report showing 0 of 56 mutations. We conclude a mutation at position 179 of Gi ...
