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  1. No Access

    Article

    Significance of urinaryN 1,N 8-diacetylspermidine andN 1,N 12-diacetylspermine as indicators of neoplastic diseases

    N 1,N 8-Diacetylspermidine (Ac2Spd) andN 1,N 12 diacetylspermine (Ac2Spm), the occurrence of which in healthy human urine was demonstrated recently, increased much more frequently and markedly than total polyami...

    Masayuki Sugimoto, Kyoko Hiramatsu… in Journal of Cancer Research and Clinical On… (1995)

  2. No Access

    Article

    Diagnostic and prognostic usefulness of N 1,N 8-diacetylspermidine and N 1,N 12-diacetylspermine in urine as novel markers of malignancy

    Recently, we found N 1,N 8-diacetylspermidine (Ac2Spd) and N 1,N 12-diacetylspermine (Ac2Spm) in human urine, and noted that their amount increased significantly in patients with urogenital malignancies. Previou...

    Kyoko Hiramatsu, Masayuki Sugimoto… in Journal of Cancer Research and Clinical On… (1997)

  3. No Access

    Article

    Pharmacokinetics of arsenic species in Japanese patients with relapsed or refractory acute promyelocytic leukemia treated with arsenic trioxide

    To investigate the pharmacokinetics of arsenic species in Japanese patients with relapsed or refractory acute promyelocytic leukemia (APL) treated with arsenic trioxide (ATO) at a daily dose of 0.15 mg/kg.

    Shinya Fujisawa, Ryuzo Ohno, Kazuyuki Shigeno… in Cancer Chemotherapy and Pharmacology (2007)

  4. No Access

    Article

    Relationships of alcohol dehydrogenase 1B (ADH1B) and aldehyde dehydrogenase 2 (ALDH2) genotypes with alcohol sensitivity, drinking behavior and problem drinking in Japanese older men

    Many East Asians have the genetic polymorphisms rs1229984 in alcohol dehydrogenase 1B (ADH1B) and rs671 in aldehyde dehydrogenase 2 (ALDH2). Here we analyzed the relationships of the two genotypes with alcohol se...

    Marowa Hashimoto, Masutaka Watanabe… in Environmental Health and Preventive Medici… (2016)

  5. No Access

    Article

    Usefulness of transabdominal ultrasonography for assessing ulcerative colitis: a prospective, multicenter study

    Transabdominal ultrasonography (US) has been reported to be a useful tool for evaluating ulcerative colitis (UC) although with less well-established data than for Crohn’s disease. This prospective multicenter ...

    Kenji Kinoshita, Takehiko Katsurada, Mutsumi Nishida… in Journal of Gastroenterology (2019)

  6. Article

    Open Access

    Intravenous tacrolimus is a superior induction therapy for acute severe ulcerative colitis compared to oral tacrolimus

    Intravenous corticosteroid is the mainstay for managing acute severe ulcerative colitis, but one-third of patients do not respond to intravenous corticosteroid. Tacrolimus, a salvage therapy before colectomy, ...

    Hiromichi Shimizu, Toshimitsu Fujii, Kenji Kinoshita, Ami Kawamoto… in BMC Gastroenterology (2021)

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