Abstract
N 1,N 8-Diacetylspermidine (Ac2Spd) andN 1,N 12 diacetylspermine (Ac2Spm), the occurrence of which in healthy human urine was demonstrated recently, increased much more frequently and markedly than total polyamines, acetylputrescine,N 1-acetylspermidine andN 8-acetylspermidine in patients with urogenital malignancies. Ac2Spd was hardly elevated in cases of benign disease, while Ac2Spm only infrequently stayed within normal limits in patients with malignant disorders. Urine samples from more than 90% of healthy persons, but fewer than 10% of patients with malignancies, gave values within normal limits for both Ac2Spd and Ac2Spm. Simultaneous reference to these diacetylpolyamines is therefore useful in distinguishing patients with malignancies from healthy persons.
Abbreviations
- Ac 2 Spd N 1 :
-
N 8-diacetylspermidine
- Ac 2 Spm N 1 :
-
N 12-diacetylspermine
References
Bachrach U (1992) Polyamines as markers of malignancy. Prog Drug Res 39:9–33
Berg GA van den, Muskiet FA, Kingma AW, Slik W van der, Halle MR (1986) Simultaneous gas-chromatographic determination of free and acetyl-conjugated polyamines in urine. Clin Chem 32:1930–1937
Hiramatsu K, Kamei S, Sugimoto M, Kinoshita K, Iwasaki K, Kawakita M (1994) An improved method of determining free and acetylated polyamines by HPLC involving an enzyme reactor and an electrochemical detector. J. Biochem (Tokyo) 115:584–589
Hiramatsu K, Sugimoto M, Kamei S, Kinoshita K, Iwasaki K, Kawakita M (1995) Determination of the amounts of polyamines excreted in urine: demonstration ofN 1,N 8-diacetylspermidine andN 1,N 12-diacetylspermine as components commonly occurring in normal human urine. J Biochem (Tokyo) 117:107–112
Löser C, Fölsch UR, Paprotny C, Creutzfeldt W (1990) Polyamines in colorectal cancer, evaluation of polyamine concentrations in colon tissue, serum, and urine of 50 patients with colorectal cancer. Cancer 65:958–966
Oesterling JE (1991) Prostate specific antigen. A critical assessment of the most useful tumor marker for adenocarcinoma of the prostate. J Urol 145:907–923
Seiler N, Knödgen B (1985) Determination of polyamines and related compounds by reversed-phase high-performance liquid chromatography: improved separation systems. J Chromatogr 339:45–57
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Sugimoto, M., Hiramatsu, K., Kamei, S. et al. Significance of urinaryN 1,N 8-diacetylspermidine andN 1,N 12-diacetylspermine as indicators of neoplastic diseases. J Cancer Res Clin Oncol 121, 317–319 (1995). https://doi.org/10.1007/BF01209602
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DOI: https://doi.org/10.1007/BF01209602