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Article
Urinary N1,N12-diacetylspermine as a biomarker for pediatric cancer: a case–control study
Minimally invasive examinations are particularly important in pediatric patients. Although the significance of urinary N1,N12-diacetylspermine (DiAcSpm) as a tumor marker (TM) has been reported in many types of a...
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Article
Open AccessUrinary N1, N12-diacetylspermine is a non-invasive marker for the diagnosis and prognosis of non-small-cell lung cancer
Early detection of non-small-cell lung cancer (NSCLC) and accurate prognostic risk assessment could improve patient outcome. We examined the significance of urinary N1, N12-diacetylspermine (DiAcSpm) in the detec...
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Article
Open AccessSignificant correlation between urinary N1, N12-diacetylspermine and tumor invasiveness in patients with clinical stage IA non-small cell lung cancer
To select optimal candidates for limited lung resection, it is necessary to accurately differentiate the non-invasive tumors from other small-sized lung cancer. Urinary N1, N12-diacetylspermine (DiAcSpm) has been...
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Chapter
N 1,N 12-Diacetylspermine in Human Urine: Performance as a Tumor Marker, Quantification, Production, and Excretion
N 1,N 12-Diacetylspermine (DiAcSpm) is a minor polyamine component of human urine. DiAcSpm levels are frequently elevated in the urine of patients suffering from various...
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Article
Increase of N 1 ,N 12-diacetylspermine in tissues from colorectal cancer and its liver metastasis
N 1 ,N 12-Diacetylspermine (DiAcSpm) is a tumor marker featured by increase in the urine of patients with cancers, including early colorect...
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Protocol
Determination of N 1,N 12-Diacetylspermine in Urine: A Novel Tumor Marker
N 1,N 12-diacetylspermine (DiAcSpm) is a minor component of human urine that constitutes less than 0.5% of total polyamine species in human urine. Structurally rel...
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Article
Diagnostic and prognostic usefulness of N 1,N 8-diacetylspermidine and N 1,N 12-diacetylspermine in urine as novel markers of malignancy
Recently, we found N 1,N 8-diacetylspermidine (Ac2Spd) and N 1,N 12-diacetylspermine (Ac2Spm) in human urine, and noted that their amount increased significantly in patients with urogenital malignancies. Previou...
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Article
Significance of urinaryN 1,N 8-diacetylspermidine andN 1,N 12-diacetylspermine as indicators of neoplastic diseases
N 1,N 8-Diacetylspermidine (Ac2Spd) andN 1,N 12 diacetylspermine (Ac2Spm), the occurrence of which in healthy human urine was demonstrated recently, increased much more frequently and markedly than total polyami...
