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Article
Multi-parametric Z-spectral MRI may have a good performance for glioma stratification in clinical patients
To comprehensively and noninvasively risk-stratify glioma grade, isocitrate dehydrogenase (IDH) genotype, and 1p/19q codeletion status using multi-contrast Z-spectral magnetic resonance imaging (MRI).
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Article
Characterization of microenvironmental changes in the intervertebral discs of patients with chronic low back pain using multiparametric MRI contrasts extracted from Z-spectrum
Z-spectral MRI data were analyzed to produce multiparametric metabolic and microenvironmental contrasts for identifying intervertebral discs with/without pain symptom and sore pain.
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Article
Characterization of the microstructure of the intervertebral disc in patients with chronic low back pain by diffusion kurtosis imaging
Multivariate analysis of T2-weighted signal, diffusion ADC, and DKI parameters and tractography were used to differentiate chronic non-specific low back pain (CLBP) patients and asymptomatic controls (AC).
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Article
Texture analysis of placental MRI: can it aid in the prenatal diagnosis of placenta accreta spectrum?
To determine if texture analysis can differentiate placenta accreta spectrum (PAS) from normal placenta on MRI.
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Article
Diffusion kurtosis imaging provides quantitative assessment of the microstructure changes of disc degeneration: an in vivo experimental study
Our aim was to assess the microstructural changes of intervertebral disc degeneration induced by annulus needle puncture in rats by diffusion kurtosis imaging (DKI).
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Article
Amid proton transfer (APT) and magnetization transfer (MT) MRI contrasts provide complimentary assessment of brain tumors similarly to proton magnetic resonance spectroscopy imaging (MRSI)
Using MRSI as comparison, we aimed to explore the difference between amide proton transfer (APT) MRI and conventional semi-solid magnetization transfer ratio (MTR) MRI, and to investigate if molecular APT and ...
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Article
Improved Differentiation of Low-Grade and High-Grade Gliomas and Detection of Tumor Proliferation Using APT Contrast Fitted from Z-Spectrum
The purpose of the study is to demonstrate the value of quantitative amide proton transfer (APT) imaging for differentiating glioma grades and detecting tumor proliferation.
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Article
Discrimination of Malignant versus Benign Mediastinal Lymph Nodes Using Diffusion MRI with an IVIM Model
To investigate the value of an intravoxel incoherent motion (IVIM) diffusion model for discriminating malignant versus benign mediastinal lymph nodes (MLN).
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Article
Creatine CEST MRI for Differentiating Gliomas with Different Degrees of Aggressiveness
Creatine (Cr) is a major metabolite in the bioenergetic system. Measurement of Cr using conventional MR spectroscopy (MRS) suffers from low spatial resolution and relatively long acquisition times. Creatine ch...
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Chapter
Influence of Free Radicals on the Intrinsic MRI Relaxation Properties
Free radicals are critical contributors in various conditions including normal aging, Alzheimer’s disease, cancer, and diabetes. Currently there is no non-invasive approach to image tissue free radicals based ...
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Chapter and Conference Paper
Magnetization Transfer MRI Contrast May Correlate with Tissue Redox State in Prostate Cancer
Develo** imaging biomarkers for non-invasive measurement of the tissue redox state is a key research area. Recently, we presented the first non-invasive MR imaging method that demonstrated the correlation be...
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Article
Open AccessT1ρ MRI of healthy and fibrotic human livers at 1.5 T
Liver fibrosis is a public health problem worldwide. There is a need of noninvasive imaging based methods for better diagnosis of this disease. In the current study, we aim to evaluate the potential of T1ρ MRI...
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Article
Breast Cancer Redox Heterogeneity Detectable with Chemical Exchange Saturation Transfer (CEST) MRI
Tissue redox state is an important mediator of various biological processes in health and diseases such as cancer. Previously, we discovered that the mitochondrial redox state of ex vivo tissues detected by redox...
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Article
Open AccessIn vivo Magnetic Resonance Imaging of Tumor Protease Activity
Increased expression of cathepsins has diagnostic as well as prognostic value in several types of cancer. Here, we demonstrate a novel magnetic resonance imaging (MRI) method, which uses poly-L-glutamate (PLG)...
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Article
A technique for in vivo map** of myocardial creatine kinase metabolism
The measurement of metabolites such as creatine, which are involved in the tissue creatine kinase reaction, enable the study of the effects of energy deprivation on the heart. Haris and colleagues introduce a ...
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Chapter and Conference Paper
In Vivo Metabolic Evaluation of Breast Tumor Mouse Xenografts for Predicting Aggressiveness Using the Hyperpolarized 13C-NMR Technique
In vivo imaging/spectroscopic biomarkers for solid tumor aggressiveness are needed in the clinic to facilitate cancer diagnosis and treatment strategies. In mouse models of human melanoma and breast cancer, we...
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Chapter and Conference Paper
Characterizing Prostate Tumor Mouse Xenografts with CEST and MT-MRI and Redox Scanning
The main goal of this study was to use multimodality imaging methods to reveal the heterogeneity in prostate cancer and seek the correlation between the characteristic heterogeneity and tumor aggressiveness. H...
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Chapter and Conference Paper
Blood Oxygen Level Dependent Magnetization Transfer (BOLDMT) Effect
A few studies have reported that magnetization transfer (MT) preparation interacts with blood oxygen level dependent (BOLD) contrast used for functional magnetic resonance imaging (MRI). However, the mechanis...
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Article
The Impact of Gabapentin Administration on Brain GABA and Glutamate Concentrations: A 7T 1H-MRS Study
Gamma-aminobutyric acid (GABA) and glutamate are implicated in numerous neuropsychiatric and substance abuse conditions, but their spectral overlap with other resonances makes them a challenge to quantify in h...
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Article
Magnetic resonance imaging of glutamate
Kejia Cai et al. describe a method to non-invasively detect glutamate (Glu) concentrations in the brain with MRI at high resolution. The approach is based on the pH-dependent chemical exchange saturation transfer...
