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Article
Multi-pool chemical exchange saturation transfer MRI in glioma grading, molecular subty** and evaluating tumor proliferation
To evaluate the performance of multi-pool Chemical exchange saturation transfer (CEST) MRI in prediction of glioma grade, isocitrate dehydrogenase (IDH) mutation, alpha-thalassemia/mental retardation syndrome ...
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Article
Cross-ancestry genome-wide association studies of brain imaging phenotypes
Genome-wide association studies of brain imaging phenotypes are mainly performed in European populations, but other populations are severely under-represented. Here, we conducted Chinese-alone and cross-ancest...
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Article
Long-term effects of childhood single-parent family structure on brain connectivity and psychological well-being
The high and increasing proportion of single-parent families is considered a risk factor associated with various childhood trauma experiences. Consequently, concerns have been raised regarding the potential lo...
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Article
Open AccessHAP40 modulates mutant Huntingtin aggregation and toxicity in Huntington’s disease mice
Huntington’s disease (HD) is a monogenic neurodegenerative disease, caused by the CAG trinucleotide repeat expansion in exon 1 of the Huntingtin (HTT) gene. The HTT gene encodes a large protein known to interact ...
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Article
Large-scale functional network connectivity mediates the association between nigral neuromelanin hypopigmentation and motor impairment in Parkinson’s disease
Neuromelanin hypopigmentation within substantia nigra pars compacta (SNc) reflects the loss of pigmented neurons, which in turn contributes to the dysfunction of the nigrostriatal and striato-cortical pathways...
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Article
Spatiotemporal patterns of brain iron-oxygen metabolism in patients with Parkinson’s disease
Iron deposition and mitochondrial dysfunction are closely associated with the genesis and progression of Parkinson’s disease (PD). This study aims to extract susceptibility and oxygen extraction fraction (OEF)...
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Article
The changes of oxygen extraction fraction in different types of lesions in relapsing–remitting multiple sclerosis: A cross-sectional and longitudinal study
To explore the oxygen metabolism level of different types of lesions in relapsing–remitting multiple sclerosis (RRMS) patients by oxygen extraction fraction (OEF) both cross-sectionally and longitudinally.
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Article
Covariation of preadult environmental exposures, adult brain imaging phenotypes, and adult personality traits
Exposure to preadult environmental exposures may have long-lasting effects on mental health by affecting the maturation of the brain and personality, two traits that interact throughout the developmental proce...
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Article
Cross-ancestry genome-wide association meta-analyses of hippocampal and subfield volumes
The hippocampus is critical for memory and cognition and neuropsychiatric disorders, and its subfields differ in architecture and function. Genome-wide association studies on hippocampal and subfield volumes a...
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Article
Structural and functional alterations within the Papez circuit in subacute stroke patients
Beyond causing local injury, stroke disrupts structural and functional organization of the brain networks, exposing patients to a high risk of cognitive impairment by affecting the neural network activity. How...
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Article
Fractional anisotropy helps to differentiate the optic nerve impairment between neuromyelitis optica spectrum disorders and multiple sclerosis
To assess the characteristics of optic nerve impairment between neuromyelitis optica spectrum disorders (NMOSD) and multiple sclerosis (MS) patients by fractional anisotropy (FA).
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Article
Open AccessManganese-based hollow nanoplatforms for MR imaging-guided cancer therapies
Theranostic nanoplatforms integrating diagnostic and therapeutic functions have received considerable attention in the past decade. Among them, hollow manganese (Mn)-based nanoplatforms are superior since they...
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Article
Global urbanicity is associated with brain and behaviour in young people
Urbanicity is a growing environmental challenge for mental health. Here, we investigate correlations of urbanicity with brain structure and function, neuropsychology and mental illness symptoms in young people...
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Article
Open AccessCortical and Subcortical Grey Matter Abnormalities in White Matter Hyperintensities and Subsequent Cognitive Impairment
Grey matter (GM) alterations may contribute to cognitive decline in individuals with white matter hyperintensities (WMH) but no consensus has yet emerged. Here, we investigated cortical thickness and grey matt...
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Article
Characterization of microenvironmental changes in the intervertebral discs of patients with chronic low back pain using multiparametric MRI contrasts extracted from Z-spectrum
Z-spectral MRI data were analyzed to produce multiparametric metabolic and microenvironmental contrasts for identifying intervertebral discs with/without pain symptom and sore pain.
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Article
Open AccessAltered regional homogeneity and functional brain networks in Type 2 diabetes with and without mild cognitive impairment
Patients with Type-2 Diabetes Mellitus (T2DM) have a considerably higher risk of develo** mild cognitive impairment (MCI) and dementia. The initial symptoms are very insidious at onset. We investigated the a...
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Article
Mitochondria determine the sequential propagation of the calcium macrodomains revealed by the super-resolution calcium lantern imaging
Despite the wide application of super-resolution (SR) microscopy in biological studies of cells, the technology is rarely used to monitor functional changes in live cells. By combining fast spinning disc-confo...
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Article
Associations Between Diffusion Dynamics and Functional Outcome in Acute and Early Subacute Ischemic Stroke
The current study aimed to investigate the associations between diffusion dynamics of ischemic lesions and clinical functional outcome of acute and early subacute stroke.
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Article
Open AccessCHIMGEN: a Chinese imaging genetics cohort to enhance cross-ethnic and cross-geographic brain research
The Chinese Imaging Genetics (CHIMGEN) study establishes the largest Chinese neuroimaging genetics cohort and aims to identify genetic and environmental factors and their interactions that are associated with ...
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Article
Open AccessSelenium-binding protein 1 transcriptionally activates p21 expression via p53-independent mechanism and its frequent reduction associates with poor prognosis in bladder cancer
Recent studies have shown that selenium-binding protein 1 (SELENBP1) is significantly down-regulated in a variety of solid tumors. Nevertheless, the clinical relevance of SELENBP1 in human bladder cancer has n...
