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Article
Open AccessSulforaphane decreases serum selenoprotein P levels through enhancement of lysosomal degradation independent of Nrf2
Selenoprotein P (SeP) is a major selenoprotein in serum predominantly produced in the liver. Excess SeP impairs insulin secretion from the pancreas and insulin sensitivity in skeletal muscle, thus inhibition o...
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Article
Open AccessNrf2 alleviates spaceflight-induced immunosuppression and thrombotic microangiopathy in mice
Spaceflight-related stresses impact health via various body systems, including the haematopoietic and immune systems, with effects ranging from moderate alterations of homoeostasis to serious illness. Oxidativ...
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Article
Open AccessConstruction of a trio-based structural variation panel utilizing activated T lymphocytes and long-read sequencing technology
Long-read sequencing technology enable better characterization of structural variants (SVs). To adapt the technology to population-scale analyses, one critical issue is to obtain sufficient amount of high-mole...
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Article
Open AccessNrf2 plays a critical role in the metabolic response during and after spaceflight
Space travel induces stresses that contribute to health problems, as well as inducing the expression of Nrf2 (NF-E2-related factor-2) target genes that mediate adaptive responses to oxidative and other stress ...
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Article
Open AccessAuthor Correction: Nrf2 contributes to the weight gain of mice during space travel
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessNrf2 contributes to the weight gain of mice during space travel
Space flight produces an extreme environment with unique stressors, but little is known about how our body responds to these stresses. While there are many intractable limitations for in-flight space research,...
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Article
Nrf2 in liver toxicology
Liver plays essential roles in the metabolism of many endogenous chemicals and exogenous toxicants. Mechanistic studies in liver have been at the forefront of efforts to probe the roles of bioactivation and de...
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Article
Open Accessp62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming
p62/Sqstm1 is a multifunctional protein involved in cell survival, growth and death, that is degraded by autophagy. Amplification of the p62/Sqstm1 gene, and aberrant accumulation and phosphorylation of p62/Sqstm...
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Article
Open AccessMultimodal corpus of multiparty conversations in L1 and L2 languages and findings obtained from it
To investigate the differences in communicative activities by the same interlocutors in Japanese (their L1) and in English (their L2), an 8-h multimodal corpus of multiparty conversations was collected. Three ...
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Keap1-Nrf2 Regulatory System and Cancer
Nrf2 is a transcription factor belonging to the Cap’n’collar (CNC) family that contains four members: Nrf1, Nrf2, Nrf3, and p45 NF-E2. Nrf2 forms a heterodimer with small Maf (sMaf) protein and binds to antiox...
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Article
Nrf2 inhibits hepatic iron accumulation and counteracts oxidative stress-induced liver injury in nutritional steatohepatitis
The transcription factor nuclear factor-E2-related factor-2 (Nrf2) is a key regulator for induction of hepatic antioxidative stress systems. We aimed to investigate whether activation of Nrf2 protects against ...
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Article
The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1
Impaired turnover of the autophagy substrate p62 leads to liver injury. p62 inhibits the ubiquitin ligase Keap1, leading to stabilization of the transcription factor Nrf2. High levels of p62 in autophagy defic...
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Article
Abnormal nocturnal blood pressure profile is associated with mild cognitive impairment in the elderly: the J-SHIPP study
Mild cognitive impairment (MCI), a syndrome characteristic of the transition phase between normal cognitive function and dementia, has been shown to carry the risk of progression to dementia. Dysregulation of ...
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Article
Toxicological Effects of Polycyclic Aromatic Hydrocarbon Quinones Contaminated in Diesel Exhaust Particles
Accumulated epidemiological and animal studies have suggested that prolonged exposure to ambient particulate matter (PM) is associated with an increased risk of cardiovascular disease and pulmonary dysfunction...
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Article
Inhibition of endothelial nitric oxide synthase activity and suppression of endothelium-dependent vasorelaxation by 1,2-naphthoquinone, a component of diesel exhaust particles
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Article
Inhibition of endothelial nitric oxide synthase activity and suppression of endothelium-dependent vasorelaxation by 1,2-naphthoquinone, a component of diesel exhaust particles
Diesel exhaust particles contain redox-active quinones, such as 9,10-phenanthraquinone (9,10-PQ) and 1,2-naphthoquinone (1,2-NQ), which act as potent electron acceptors, thereby altering electron transfer on p...
