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Article
Open AccessTrajectory pattern of serially measured acute kidney injury biomarkers in critically ill patients: a prospective observational study
The clinical value of the trajectory of temporal changes in acute kidney injury (AKI) biomarkers has not been well established among intensive care unit (ICU) patients.
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Article
Open AccessThe care burden for technology-dependent children with long-term home ventilation increases along with the improvement of their motor functions
Since the establishment of Japan’s publicly supported pediatric home medical care (PHMC) system in 2012, the number of technology-dependent children (TDC) who are supported by PHMC has been increasing. We expe...
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Article
Open AccessChanges in carbon dioxide production and oxygen uptake evaluated using indirect calorimetry in mechanically ventilated patients with sepsis
Several clinical guidelines recommend monitoring blood lactate levels and central venous oxygen saturation for hemodynamic management of patients with sepsis. We hypothesized that carbon dioxide production (VCO2)...
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Article
Open AccessPulse oximetry-based capillary refilling evaluation predicts postoperative outcomes in liver transplantation: a prospective observational cohort study
Capillary refill time (CRT) is a non-invasive technique to evaluate tissue perfusion, and quantitative CRT (Q-CRT) adapted to pulse oximetry was developed with patients with sepsis and compared to blood lactat...
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Article
Open AccessOrgan system network analysis and biological stability in critically ill patients
Continuous coordination among organ systems is necessary to maintain biological stability in humans. Organ system network analysis in addition to organ-oriented medicine is expected to improve patient outcomes...
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Article
Distinct hormonal regulation of two types of sexual dimorphism in submandibular gland of mice
The submandibular gland (SMG) of mice exhibits prominent sexual dimorphism in two aspects: the preferential development of granular convoluted tubule (GCT) cells and the earlier disappearance of granular inter...
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Article
Synthesis, localization and possible function of serine (or cysteine) peptidase inhibitor, clade B, member 6a (Serpinb6a) in mouse submandibular gland
The granular convoluted tubule (GCT) in the duct system of the submandibular gland (SMG) develops preferentially in male mice and produces a number of bioactive peptides including proteases such as renin and k...
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Article
Open AccessRetinoic acid regulates cell-shape and -death of E-FABP (FABP5)-immunoreactive septoclasts in the growth plate cartilage of mice
Septoclasts, which are mononuclear and spindle-shaped cells with many processes, have been considered to resorb the transverse septa of the growth plate (GP) cartilage at the chondro-osseous junction (COJ). We...
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Article
Immunohistochemical localization of keratin 5 in the submandibular gland in adult and postnatal develo** mice
Keratin 5 (K5) is a marker of basal progenitor cells in the epithelia of a number of organs. During prenatal development of the submandibular gland (SMG) in mice, K5+ progenitor cells in the develo** epithelia ...
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Article
Expression of epidermal fatty acid binding protein (E-FABP) in septoclasts in the growth plate cartilage of mice
n-3 Polyunsaturated fatty acids play a role in regulating the growth of the long bones. Fatty acid-binding proteins (FABPs) bind and transport hydrophobic long-chain fatty acids intracellularly, and epidermal-...
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Article
An anterior chest wall abscess penetrating the pleural cavity
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Article
Abnormal nocturnal blood pressure profile is associated with mild cognitive impairment in the elderly: the J-SHIPP study
Mild cognitive impairment (MCI), a syndrome characteristic of the transition phase between normal cognitive function and dementia, has been shown to carry the risk of progression to dementia. Dysregulation of ...
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Article
Expression of cAMP response element-binding protein in the duct system of the mouse submandibular gland
The submandibular gland (SMG) of mice shows a marked sexual dimorphism in which a duct portion called the granular convoluted tubule (GCT) is developed preferentially in males during puberty. The administratio...
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Article
Interaction between Serotonin 2A Receptor and Endothelin-1 Variants in Association with Hypertension in Japanese
Serotonin has been implicated in the pathogenesis of hypertension because of its ability to induce vasoconstriction via stimulation of serotonin 2 (5-HT2) receptors. Recently, an association between the T102C fun...
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Article
Hypotension Associated with Prone Body Position: A Possible Overlooked Postural Hypotension
Conditions related to the dysregulation of blood pressure (BP), such as orthostatic hypotension, have been shown to be significantly associated with cardiovascular disease. Recently, the prone body position ha...
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Article
Association of Dopamine β-Hydroxylase Polymorphism with Hypertension through Interaction with Fasting Plasma Glucose in Japanese
Dopamine-β-hydroxylase (DBH) catalyzes the conversion of dopamine to norepinephrine and is released from sympathetic neurons into the circulation. Several lines of evidence, including the finding of elevated plas...
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Article
Accelerated recognition of left oblique views of faces
Because faces in portraits are depicted more frequently in a left rather than a right oblique (half-profile or 3/4) view, we addressed the question of whether people find it easier to recognize the left or rig...
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Article
The expression of platelet endothelial cell adhesion molecule-1 in mouse primordial germ cells during their migration and early gonadal formation
The platelet endothelial cell adhesion molecule-1 (PECAM-1), or CD31, a member of the immunoglobulin superfamily, is located on the plasma membrane of endothelial and hematopoietic cells and involved in vascul...
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Article
Different expression of 25-kDa heat-shock protein (Hsp25) in Meckel's cartilage compared with other cartilages in the mouse
The 25-kDa heat-shock protein (Hsp25) is expressed in the cartilage of the growth plate and suggested to function in chondrocyte differentiation and degeneration. Using immunohistochemistry, we examined the te...
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Article
Initiation of smooth pursuit in humans
We examined the influence of target saliency on the initiation of smooth pursuit. The eye movements of five human subjects were recorded with the scleral search-coil technique. A video-projection system was u...
