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Article
A novel method for selective isotope labeling of bacterially expressed proteins
A novel method for isotope labeling in selected amino acids is presented for use with the T7 RNA polymerase system. The protocol is illustrated with the DNA-binding domain from the E2 protein of bovine papillo...
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Article
1H, 15N, and 13C NMR resonance assignments for the DNA-binding domain of the BPV-1 E2 protein
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Article
The Problem of Protocol Driven Costs in Pharmacoeconomic Analysis
The increasing number of economic evaluations of healthcare interventions and of drug therapies in particular has been well documented. Surveys of the quality of studies have demonstrated that standards of con...
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Article
Cost Effectiveness of Epoetin-α to Augment Preoperative Autologous Blood Donation in Elective Cardiac Surgery
Objective: The objective of this study was to assess the cost effectiveness of using epoetin-α (erythropoietin) to augment preoperative autologous donation (PAD) of blood prior to elective cardia...
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Article
Cost Effectiveness of Nasal Calcitonin in Postmenopausal Women
Objective: To assess the cost effectiveness of nasal calcitonin (Miacalcin®) compared with no therapy, alendronate or etidronate in the treatment of postmenopausal women with previous osteoporoti...
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Article
The Role of Models Within Economic Analysis
Economic analysis of healthcare interventions is increasingly reliant on decision models to estimate the long- term costs and benefits of new therapies. Models permit analysts to take short-term clinical data ...
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Article
Phase Ib study of dovitinib in combination with gemcitabine plus cisplatin or gemcitabine plus carboplatin in patients with advanced solid tumors
Dovitinib is a small molecule kinase inhibitor with activity against the fibroblast growth factor and vascular endothelial growth factor receptor families. The purpose of this phase Ib study was to define the...
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Article
Phase 2 trial of the topoisomerase II inhibitor, amrubicin, as second-line therapy in patients with metastatic urothelial carcinoma
The purpose of this investigator-initiated multicenter phase II study was to determine the activity of the third-generation synthetic anthracycline, amrubicin, administered as second-line therapy in patients w...
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Article
Open AccessOutcomes assessment in intrahepatic cholangiocarcinoma using qualitative and quantitative imaging features
To assess the performance of imaging features, including radiomics texture features, in predicting histopathologic tumor grade, AJCC stage, and outcomes [time to recurrence (TTR) and overall survival (OS)] in ...
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Article
Comparative assessment of standard and immune response criteria for evaluation of response to PD-1 monotherapy in unresectable HCC
To assess response to programmed death-1 (PD-1) monotherapy (nivolumab) in hepatocellular carcinoma (HCC) patients using RECIST1.1, modified RECIST (mRECIST), and immune RECIST (iRECIST). A secondary objective...
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Article
HCC screening with ultrasound: assessment of quality using ultrasound LI-RADS score
To describe ultrasound (US) quality for hepatocellular carcinoma (HCC) screening/surveillance using the US LI-RADS scoring system, and to assess predictive factors of worse US quality scores.
