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Article
Delineating cell behavior and metabolism of non-melanoma skin cancer in vitro
Non-melanoma skin cancers - basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) - are the most frequent forms of malignant neoplasm in humans worldwide. The etiology of these carcinomas is multifactor...
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Chapter
Applications of NMR in Cancer Research
Nuclear magnetic resonance (NMR) spectroscopy has been widely applied to many facets of cancer research. As the name implies, NMR spectroscopy is a technique that utilizes transitions between different states ...
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Article
Backbone resonance assignments of the C2 domain of coagulation factor VIII
Factor VIII (FVIII, other clotting factors are named similarly) is a glycoprotein that circulates in the plasma bound to von Willebrand factor. During the blood coagulation cascade, activated FVIII (FVIIIa) bi...
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Article
Letter to the Editor: 1H, 15N, and 13C NMR resonance assignments for the Eps15 homology domain of Reps1
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Article
SMN oligomerization defect correlates with spinal muscular atrophy severity
Spinal muscular atrophy (SMA) is a motor-neuron disorder resulting from anterior-horn–cell death. The autosomal recessive form has a carrier frequency of 1 in 50 and is the most common genetic cause of infant ...
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Article
1H, 15N, and 13C NMR resonance assignments for the DNA-binding domain of the BPV-1 E2 protein
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Article
Refined solution structure of the DNA-binding domain of GAL4 and use of 3J(113Cd,1H) in structure determination
We have refined the solution structure of cadmium-bound GAL4 and present its15 N and 1H NMR assignments. The root-mean-square (rms) deviation to the average structure was 0.4 ± 0.05 Å for backbone atoms, and 0.9 ...
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Article
A novel method for selective isotope labeling of bacterially expressed proteins
A novel method for isotope labeling in selected amino acids is presented for use with the T7 RNA polymerase system. The protocol is illustrated with the DNA-binding domain from the E2 protein of bovine papillo...
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Article
Solution structure of the DNA-binding domain of Cd2-GAL4 from S. cerevisiae
THE GAL4 protein activates transcription of the genes required for galactose utilization in Saccharomyces cerevisiae1. The protein, consisting of 881 amino acids, is dimeric when bound to one of the approximately...