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Article
An exclusive metabolic niche enables strain engraftment in the gut microbiota
The dense microbial ecosystem in the gut is intimately connected to numerous facets of human biology, and manipulation of the gut microbiota has broad implications for human health. In the absence of profound ...
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Article
C. difficile exploits a host metabolite produced during toxin-mediated disease
Several enteric pathogens can gain specific metabolic advantages over other members of the microbiota by inducing host pathology and inflammation. The pathogen Clostridium difficile is responsible for a toxin-med...
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Article
Open AccessOxidative ornithine metabolism supports non-inflammatory C. difficile colonization
The enteric pathogen Clostridioides difficile (Cd) is responsible for a toxin-mediated infection that causes more than 200,000 recorded hospitalizations and 13,000 deaths in the United States every year1. However...
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Article
Open AccessHost-microbe co-metabolism via MCAD generates circulating metabolites including hippuric acid
The human gut microbiota produces dozens of small molecules that circulate in blood, accumulate to comparable levels as pharmaceutical drugs, and influence host physiology. Despite the importance of these meta...
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Article
Open AccessPrevotella copri and microbiota members mediate the beneficial effects of a therapeutic food for malnutrition
Microbiota-directed complementary food (MDCF) formulations have been designed to repair the gut communities of malnourished children. A randomized controlled trial demonstrated that one formulation, MDCF-2, im...
