25 Result(s)
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Justin L. Sonnenburg
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High-throughput identification of gut microbiome-dependent metabolites
A significant hurdle that has limited progress in microbiome science has been identifying and studying the diverse set of metabolites produced by gut microbes. Gut microbial metabolism produces thousands of di...
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Bacteroides fragilis toxin expression enables lamina propria niche acquisition in the develo** mouse gut
Bacterial toxins are well-studied virulence factors; however, recent studies have revealed their importance in bacterial niche adaptation. Enterotoxigenic Bacteroides fragilis (ETBF) expresses B. fragilis toxin (...
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Open AccessHost-microbe co-metabolism via MCAD generates circulating metabolites including hippuric acid
The human gut microbiota produces dozens of small molecules that circulate in blood, accumulate to comparable levels as pharmaceutical drugs, and influence host physiology. Despite the importance of these meta...
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Open AccessOxidative ornithine metabolism supports non-inflammatory C. difficile colonization
The enteric pathogen Clostridioides difficile (Cd) is responsible for a toxin-mediated infection that causes more than 200,000 recorded hospitalizations and 13,000 deaths in the United States every year1. However...
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Reporting guidelines for human microbiome research: the STORMS checklist
The particularly interdisciplinary nature of human microbiome research makes the organization and reporting of results spanning epidemiology, biology, bioinformatics, translational medicine and statistics a ch...
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A metabolomics pipeline for the mechanistic interrogation of the gut microbiome
Gut microorganisms modulate host phenotypes and are associated with numerous health effects in humans, ranging from host responses to cancer immunotherapy to metabolic disease and obesity. However, difficulty ...
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C. difficile exploits a host metabolite produced during toxin-mediated disease
Several enteric pathogens can gain specific metabolic advantages over other members of the microbiota by inducing host pathology and inflammation. The pathogen Clostridium difficile is responsible for a toxin-med...
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Phase-variable capsular polysaccharides and lipoproteins modify bacteriophage susceptibility in Bacteroides thetaiotaomicron
A variety of cell surface structures dictate interactions between bacteria and their environment, including their viruses (bacteriophages). Members of the human gut Bacteroidetes characteristically produce sev...
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Klebsiella michiganensis transmission enhances resistance to Enterobacteriaceae gut invasion by nutrition competition
Intestinal microbiotas contain beneficial microorganisms that protect against pathogen colonization; treatment with antibiotics disrupts the microbiota and compromises colonization resistance. Here, we determi...
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The ancestral and industrialized gut microbiota and implications for human health
Human-associated microbial communities have adapted to environmental pressures. Doses of antibiotics select for a community with increased antibiotic resistance, inflammation is accompanied by expansion of com...
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Open AccessSmall intestinal microbial dysbiosis underlies symptoms associated with functional gastrointestinal disorders
Small intestinal bacterial overgrowth (SIBO) has been implicated in symptoms associated with functional gastrointestinal disorders (FGIDs), though mechanisms remain poorly defined and treatment involves non-sp...
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Microbiota-accessible carbohydrates suppress Clostridium difficile infection in a murine model
Clostridium difficile is an opportunistic diarrhoeal pathogen, and C. difficile infection (CDI) represents a major health care concern, causing an estimated 15,000 deaths per year in the United States alone ...
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An exclusive metabolic niche enables strain engraftment in the gut microbiota
The dense microbial ecosystem in the gut is intimately connected to numerous facets of human biology, and manipulation of the gut microbiota has broad implications for human health. In the absence of profound ...
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A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites
A pathway for the production of aromatic amino acid metabolites in Clostridium sporogenes is described; modulation of serum levels of these metabolites in gnotobiotic mice affects intestinal permeability and syst...
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Diet–microbiota interactions as moderators of human metabolism
It is widely accepted that obesity and associated metabolic diseases, including type 2 diabetes, are intimately linked to diet. However, the gut microbiota has also become a focus for research at the intersect...
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Diet-induced extinctions in the gut microbiota compound over generations
In mice on a low microbiota-accessible carbohydrate (MAC) diet, the diversity of the gut microbiota is depleted, and the effect is transferred and compounded over generations; this phenotype is only reversed a...
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A personal forecast
Machine learning, applied to complex multidimensional data, is shown to provide personalized dietary recommendations to control blood glucose levels. This is a step towards integrating the gut microbiome into ...
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Your gut microbiome, deconstructed
Use of sophisticated reductionist and whole-system approaches are providing much-needed technologies to unravel the complex mélange of microbiome functions.
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Open AccessMetabolome progression during early gut microbial colonization of gnotobiotic mice
The microbiome has been implicated directly in host health, especially host metabolic processes and development of immune responses. These are particularly important in infants where the gut first begins being...
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Microbiome Engineering
Synthetic biology may lead to the creation of smart microbes that can detect and treat disease
