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  1. Article

    Open Access

    Host-microbe co-metabolism via MCAD generates circulating metabolites including hippuric acid

    The human gut microbiota produces dozens of small molecules that circulate in blood, accumulate to comparable levels as pharmaceutical drugs, and influence host physiology. Despite the importance of these meta...

    Kali M. Pruss, Haoqing Chen, Yuanyuan Liu, William Van Treuren… in Nature Communications (2023)

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  2. No Access

    Protocol

    Targeted Quantification of Amino Acids by Dansylation

    Quantification of amino acids in biological samples is a critical tool for studying metabolism. Although many methods for amino acid analysis exist, important considerations include ease of sample preparation,...

    Yuanyuan Liu, Haoqing Chen, Dylan Dodd in Metabolic Reprogramming (2023)

  3. No Access

    Article

    Clostridium sporogenes uses reductive Stickland metabolism in the gut to generate ATP and produce circulating metabolites

    Gut bacteria face a key problem in how they capture enough energy to sustain their growth and physiology. The gut bacterium Clostridium sporogenes obtains its energy by utilizing amino acids in pairs, coupling th...

    Yuanyuan Liu, Haoqing Chen, William Van Treuren, Bi-Huei Hou… in Nature Microbiology (2022)