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Article
Open AccessHost-microbe co-metabolism via MCAD generates circulating metabolites including hippuric acid
The human gut microbiota produces dozens of small molecules that circulate in blood, accumulate to comparable levels as pharmaceutical drugs, and influence host physiology. Despite the importance of these meta...
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Article
Clostridium sporogenes uses reductive Stickland metabolism in the gut to generate ATP and produce circulating metabolites
Gut bacteria face a key problem in how they capture enough energy to sustain their growth and physiology. The gut bacterium Clostridium sporogenes obtains its energy by utilizing amino acids in pairs, coupling th...
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Article
Open AccessOxidative ornithine metabolism supports non-inflammatory C. difficile colonization
The enteric pathogen Clostridioides difficile (Cd) is responsible for a toxin-mediated infection that causes more than 200,000 recorded hospitalizations and 13,000 deaths in the United States every year1. However...
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Article
Microbiota-accessible carbohydrates suppress Clostridium difficile infection in a murine model
Clostridium difficile is an opportunistic diarrhoeal pathogen, and C. difficile infection (CDI) represents a major health care concern, causing an estimated 15,000 deaths per year in the United States alone ...
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Article
A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites
A pathway for the production of aromatic amino acid metabolites in Clostridium sporogenes is described; modulation of serum levels of these metabolites in gnotobiotic mice affects intestinal permeability and syst...
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Article
Open AccessHarnessing microbiome and probiotic research in sub-Saharan Africa: recommendations from an African workshop
To augment capacity-building for microbiome and probiotic research in Africa, a workshop was held in Nairobi, Kenya, at which researchers discussed human, animal, insect, and agricultural microbiome and probio...
