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  1. Article

    Open Access

    Host-microbe co-metabolism via MCAD generates circulating metabolites including hippuric acid

    The human gut microbiota produces dozens of small molecules that circulate in blood, accumulate to comparable levels as pharmaceutical drugs, and influence host physiology. Despite the importance of these meta...

    Kali M. Pruss, Haoqing Chen, Yuanyuan Liu, William Van Treuren… in Nature Communications (2023)

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  2. No Access

    Article

    C. difficile exploits a host metabolite produced during toxin-mediated disease

    Several enteric pathogens can gain specific metabolic advantages over other members of the microbiota by inducing host pathology and inflammation. The pathogen Clostridium difficile is responsible for a toxin-med...

    Kali M. Pruss, Justin L. Sonnenburg in Nature (2021)

  3. No Access

    Article

    An exclusive metabolic niche enables strain engraftment in the gut microbiota

    The dense microbial ecosystem in the gut is intimately connected to numerous facets of human biology, and manipulation of the gut microbiota has broad implications for human health. In the absence of profound ...

    Elizabeth Stanley Shepherd, William C. DeLoache, Kali M. Pruss… in Nature (2018)