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Article
Open AccessEfficacy and safety of once-weekly tirzepatide for weight management compared to placebo: An updated systematic review and meta-analysis including the latest SURMOUNT-2 trial
Tirzepatide, a newly developed dual glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist, has received approval for treating type 2 diabetes (T2D) and is currentl...
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Article
Publisher Correction: Rational design of a ‘two-in-one’ immunogen DAM drives potent immune response against mpox virus
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Article
Rational design of a ‘two-in-one’ immunogen DAM drives potent immune response against mpox virus
The global outbreak of the mpox virus (MPXV) in 2022 highlights the urgent need for safer and more accessible new-generation vaccines. Here, we used a structure-guided multi-antigen fusion strategy to design a...
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Article
Open AccessInter-basin surface water transfers database for public water supplies in conterminous United States, 1986–2015
The manipulation of water resources is a common human solution to water-related problems. Of particular interest because of impacts on both source and destination is the anthropogenic movement of water from on...
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Article
Open AccessVisualizing hypoxic modulation of beta cell secretions via a sensor augmented oxygen gradient
One distinct advantage of microfluidic-based cell assays is their scalability for multiple concentrations or gradients. Microfluidic scaling can be extremely powerful when combining multiple parameters and mod...
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Article
Open AccessCOVID-19 vaccination boosts the potency and breadth of the immune response against SARS-CoV-2 among recovered patients in Wuhan
The immunity of patients who recover from coronavirus disease 2019 (COVID-19) could be long lasting but persist at a lower level. Thus, recovered patients still need to be vaccinated to prevent reinfection by ...
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Article
Open AccessPhosphorylation of Jhd2 by the Ras-cAMP-PKA(Tpk2) pathway regulates histone modifications and autophagy
Cells need to coordinate gene expression with their metabolic states to maintain cell homeostasis and growth. How cells transduce nutrient availability to appropriate gene expression remains poorly understood....
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Article
Open AccessStructural basis of a two-antibody cocktail exhibiting highly potent and broadly neutralizing activities against SARS-CoV-2 variants including diverse Omicron sublineages
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs), especially the latest Omicron, have exhibited severe antibody evasion. Broadly neutralizing antibodies with high pot...
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Article
The evolution of eutectic microstructure and mechanical properties of AlxCoCrFeNi2.1 high-entropy alloys
In order to reveal the evolution of microstructure and properties of AlCoCrFeNi2.1 eutectic high-entropy alloy (EHEA) near the eutectic composition, a series of AlxCoCrFeNi2.1 high-entropy alloys (HEAs) were prep...
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Article
Open AccessAuthor Correction: Twelve-month specific IgG response to SARS-CoV-2 receptor-binding domain among COVID-19 convalescent plasma donors in Wuhan
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Article
Open AccessScreening of potent neutralizing antibodies against SARS-CoV-2 using convalescent patients-derived phage-display libraries
As the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to threaten public health worldwide, the development of effective interventions is urgently needed. Neutralizing antibodies (nAbs) ...
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Article
Open AccessThe value of GATA6 immunohistochemistry and computer-assisted diagnosis to predict clinical outcome in advanced pancreatic cancer
Combination chemotherapy, either modified FOLFIRINOX (mFFX) or gemcitabine–nabpaclitaxel, are used in the treatment of most patients with advanced pancreatic ductal adenocarcinoma (PDAC), yet robust biomarkers...
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Article
Open AccessTwelve-month specific IgG response to SARS-CoV-2 receptor-binding domain among COVID-19 convalescent plasma donors in Wuhan
To investigate the duration of humoral immune response in convalescent coronavirus disease 2019 (COVID-19) patients, we conduct a 12-month longitudinal study through collecting a total of 1,782 plasma samples ...
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Article
Open AccessFunctional comparison of SARS-CoV-2 with closely related pangolin and bat coronaviruses
The origin and intermediate host for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is yet to be determined. Coronaviruses found to be closely related to SARS-CoV-2 include RaTG13 derived from ba...
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Chapter and Conference Paper
Service Capability Optimization Algorithm for Power Communication Network Service Providers in Competitive Game Environment
In order to solve the problem of low resource utilization rate of multiple power communication network service providers, this paper proposes a power communication network resource management system, which con...
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Article
Immunohistochemical Analysis of the Metabolic Phenotype of Adrenal Cortical Carcinoma
Metabolic reprogramming is a cellular process contributing to carcinogenesis. However, it remains poorly understood in adrenal cortical carcinoma (ACC), an aggressive malignancy with overall poor prognosis and...
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Article
Expanding the Spectrum of Colonic Manifestations in Tuberous Sclerosis: L-Cell Neuroendocrine Tumor Arising in the Background of Rectal PEComa
Tuberous sclerosis complex (TSC) is an autosomal dominant neurocutaneous condition that predisposes to numerous proliferative lesions, including perivascular epithelioid cell tumors (PEComas), such as lymphang...
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Article
Xanthomatous Hypophysitis Is Associated with Ruptured Rathke’s Cleft Cyst
Xanthomatous hypophysitis is a rare inflammatory disease of the pituitary gland that can mimic a neoplastic lesion clinically and radiologically. Its pathogenesis remains largely unknown, although recent evide...
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Article
Safety and Immunogenicity of Pneumococcal Conjugate Vaccine in Preterm Infants: A Meta-Analysis
To assess the safety and immunogenicity of pneumococcal conjugate vaccine (PCVs) in preterm infants.
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Article
Impact of air pollution induced climate change on water availability and ecosystem productivity in the conterminous United States
Air pollution from greenhouse gases and atmospheric aerosols are the major driving force of climate change that directly alters the terrestrial hydrological cycle and ecosystem functions. However, most current...
