-
Article
Open AccessIRF4 and BATF are critical for CD8+ T-cell function following infection with LCMV
CD8+ T-cell functions are critical for preventing chronic viral infections by eliminating infected cells. For healthy immune responses, beneficial destruction of infected cells must be balanced against immunopath...
-
Article
Antimicrobial effects of murine mesenchymal stromal cells directed against Toxoplasma gondii and Neospora caninum: role of immunity-related GTPases (IRGs) and guanylate-binding proteins (GBPs)
Mesenchymal stromal cells (MSCs) have a multilineage differentiation potential and provide immunosuppressive and antimicrobial functions. Murine as well as human MSCs restrict the proliferation of T cells. How...
-
Article
Phosphorylation of Atg5 by the Gadd45β–MEKK4-p38 pathway inhibits autophagy
Autophagy is a lysosomal degradation pathway important for cellular homeostasis, mammalian development, cancer and immunity. Many molecular components of autophagy have been identified, but little is known abo...
-
Article
Open AccessOutbreak of carbapenem-resistent Acinetobacter baumannii (CRAB) in a surgical department of a university hospital
-
Article
15. Mainzer Allergie-Workshop 2003
-
Chapter and Conference Paper
Colon Ascendens Stent Peritonitis (CASP) vs. Cöcale Ligatur und Punktion (CLP) in der Maus. Ein Vergleich zweier Modelle für polymikrobielle intraabdominelle Infektion
Die postoperative Sepsis ist nach wie vor eine oft letal endende Komplikation nach großen abdominalchirurgischen Eingriffen. Da klinische Studien basierend auf Ergebnissen aus Bolusinjektionsmodellen (z. B. LP...
-
Chapter and Conference Paper
Die Rolle von IL-12 und IL-18 in der murinen intraabdominellen Sepsis
Abdominal sepsis remains the major cause of postoperative mortality in SICUs. The animal model of abdominal sepsis colon ascendens stent peritonitis (CASP) closely resembles the course of human patients suffer...
-
Chapter
4. Genetik-Workshop des Robert Koch-Instituts 2/99 in Berlin
Seit 1992 sind im Bundesgesundheitsamt (BGA) und später in dessen Nachfolgeeinrichtung, dem Robert Koch-Institut (RKI), bisher drei Experten-Veranstaltungen zu Themen der experimentellen Genetik du...
-
Chapter
Induction of Peripheral Tolerance to Class I MHC Alloantigens in Adult Mice
A major goal of transplantation immunology is to define gentle methods able to convert immune reactivity to transplantation antigens into a state of immune unresponsiveness. It is well known that this conversi...
-
Chapter and Conference Paper
T-Zell-Rezeptorrepertoire und Zytokinproduktion von humanen Darmlymphozyten
Das intestinale Immunsystem beherbergt nicht nur ca. 50–70% aller lymphatischen Zellen des Gesamtorganismus und ist somit das größte lymphatische Organ im Körper, sondern verrichtet aufgrund seiner ständigen E...
-
Chapter
Phenotypic and Functional Characterization of Human TCRγδ+ Intestinal Intraepithelial Lymphocytes
Intestinal intraepithelial lymphocytes (IEL) appear to represent a peculiar set of immune cells compartmentalized at the interface between the organism and the external environment. In previous studies we obse...
-
Chapter and Conference Paper
Funktion und Spezifität von humanen γδ T-Zellen
T-Lymphozyten erkennen Antigene mittels ihres individuellen T-Zell-Rezeptors (TZR). Dieser TZR definiert die Spezifität der T-Zelle und besteht aus 2 Polypeptidketten, die mit den invarianten Proteinen des CD ...
-
Chapter
Analysis of Primary T Cell Responses to Intact and Fractionated Microbial Pathogens
Freshly isolated human T lymphocytes were tested for their response to mycobacteria, mycobacterial lysates, 2 dimensional (2D) PAGE separated mycobacterial lysates, leishmania and defined leishmanial antigen p...
