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Article
Open AccessMultidisciplinary management of locally recurrent rectal cancer with carbon ion radiotherapy followed by prophylactic removal of the irradiated bowel: a case report
Locally recurrent rectal cancer (LRRC) involving the upper sacrum is typically incurable, and palliative treatment is the only option for most patients, resulting in a poor prognosis and reduced quality of lif...
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Article
Open AccessAuthor Correction: Proof-of-principle experiment for laser-driven cold neutron source
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessProof-of-principle experiment for laser-driven cold neutron source
The scientific and technical advances continue to support novel discoveries by allowing scientists to acquire new insights into the structure and properties of matter using new tools and sources. Notably, neut...
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Article
Development of a Method for Determining the Search Window for Solar Flare Neutrinos
Neutrinos generated during solar flares remain elusive. However, after 50 years of discussion and search, the potential knowledge unleashed by their discovery keeps the search crucial. Neutrinos associated wit...
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Chapter and Conference Paper
Pathway to Atomic-Switch Based Programmable Logic
Atomic switch featuring non-volatility, large on/off conductance ratio, and small foot print advantageously applies to programmable logic such as field programmable gate array (FPGA). FPGA is a reconfigurable ...
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Chapter
The 2017 July Northern Kyushu Torrential Rainfall Disaster—Geotechnical and Geological Perspectives
In July 2017, localized and torrential rainfall caused many landslides, debris flows, and flooding of rivers resulting in devastating damage to several areas of the Fukuoka and Oita prefectures of Kyushu, Japa...
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Article
Open AccessMarked lateral deviation of the phrenic nerve due to variant origin and course of the thyrocervical trunk: a cadaveric study
Phrenic nerve impairment can often lead to serious respiratory disorders under various pathological conditions. During routine dissection of an 88-year-old Japanese male cadaver, a victim of heart failure, we ...
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Chapter
Deformation Behavior of Friction Stir Processed Magnesium Alloys
The present study explores the feasibility of using friction stir processing to produce high-performance Mg alloy sheet. Deformation behavior of friction stir processed Mg alloys is addressed. Analyses of grai...
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Chapter
Friction Stir Welding of Magnesium Oil Pan
In this research, the feasibility of FSW dissimilar magnesium alloys was investigated. Specifically, die cast magnesium MRI-153M and AZ31 (plate) were butt-welded using the FSW technique. The effects of weld p...
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Article
Open AccessMicroRNA-574-3p, identified by microRNA library-based functional screening, modulates tamoxifen response in breast cancer
Most primary breast cancers express estrogen receptor α and can be treated via endocrine therapy using anti-estrogens such as tamoxifen; however, acquired endocrine resistance is a critical issue. To identify ...
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Article
Open AccessOverexpression of SMYD2 contributes to malignant outcome in gastric cancer
SET and MYND domain-containing protein 2 (SMYD2) is a lysine methyltransferase for histone H3, p53 and Rb and inhibits their transactivation activities. In this study, we tested whether SMYD2 (1q42) acts as a can...
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Article
Open AccessB-RAF mutation and accumulated gene methylation in aberrant crypt foci (ACF), sessile serrated adenoma/polyp (SSA/P) and cancer in SSA/P
Sessile serrated adenomas/polyps (SSA/Ps) are a putative precursor of colon cancer with microsatellite instability (MSI). However, the developmental mechanism of SSA/P remains unknown. We performed genetic ana...
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Article
Open AccessPlasma microRNA profiles: identification of miR-25 as a novel diagnostic and monitoring biomarker in oesophageal squamous cell carcinoma
Recent studies have demonstrated that microRNAs are stably detectable in plasma/serum because of their binding to specific proteins or being packaged in secretory particles. This study was designed to detect n...
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Article
Microstructures and Thermal Properties of Cold-Sprayed Cu-Cr Composite Coatings
Copper-based composites for thermal conductive components were prepared via the cold spray process, and the deposition efficiency and adhesion morphology of feedstock powders on Cu substrate were evaluated. Cu...
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Article
Open AccessClinical impact of circulating miR-18a in plasma of patients with oesophageal squamous cell carcinoma
Several recent studies demonstrated that microRNAs are stably detectable in plasma/serum. We tested whether miR-18a, which is located in the miR-17-92 cluster and reported to be highly expressed in tissues of ...
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Article
Open AccessOverexpression of YWHAZ relates to tumor cell proliferation and malignant outcome of gastric carcinoma
Several studies have demonstrated that YWHAZ (14-3-3ζ), included in the 14-3-3 family of proteins, has been implicated in the initiation and progression of cancers. We tested whether YWHAZ acted as a cancer-promo...
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Article
Open AccessClinical impact of circulating miR-221 in plasma of patients with pancreatic cancer
Several recent studies have demonstrated that microRNAs (miRNAs) are stably detectable in plasma/serum. We tested miR-221 and miR-375, which are frequently reported to be highly and poorly expressed in pancrea...
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Article
Reduced expression of BTBD10, an Akt activator, leads to motor neuron death
BTBD10, an Akt interactor, activates Akt by decreasing the protein phosphatase 2A-mediated dephosphorylation and inactivation of Akt. Overexpression of BTBD10 suppresses motor neuron death that is induced by a...
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Article
Open AccessDetection of gastric cancer-associated microRNAs on microRNA microarray comparing pre- and post-operative plasma
Recently, it was reported that plasma microRNAs (miRNAs) are low-invasive useful biomarkers for cancer. We attempted to isolate gastric cancer (GC)-associated miRNAs comparing pre- and post-operative paired pl...
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Article
Open AccessNovel diagnostic value of circulating miR-18a in plasma of patients with pancreatic cancer
Several recent studies have demonstrated that microRNAs (miRNAs) are stably detectable in the plasma/serum. We hypothesised that miR-18a in the plasma is a potential biomarker in patients with pancreatic cancer.
