-
Article
High-Fat Diet-Induced Diabetic Conditions Exacerbate Cognitive Impairment in a Mouse Model of Alzheimer’s Disease Via a Specific Tau Phosphorylation Pattern
Epidemiological evidence has demonstrated a clear association between diabetes mellitus and increased risk of Alzheimer’s disease (AD). Cerebral accumulation of phosphorylated tau aggregates, a cardinal neurop...
-
Article
Blood identification and discrimination between human and nonhuman blood using portable Raman spectroscopy
Raman spectroscopy is commonly used in chemistry to identify molecular structure. This technique is a nondestructive analysis and needs no sample preparation. Recently, Raman spectroscopy has been shown to be ...
-
Article
Open AccessClinical impact of circulating miR-18a in plasma of patients with oesophageal squamous cell carcinoma
Several recent studies demonstrated that microRNAs are stably detectable in plasma/serum. We tested whether miR-18a, which is located in the miR-17-92 cluster and reported to be highly expressed in tissues of ...
-
Article
Open AccessOverexpression of YWHAZ relates to tumor cell proliferation and malignant outcome of gastric carcinoma
Several studies have demonstrated that YWHAZ (14-3-3ζ), included in the 14-3-3 family of proteins, has been implicated in the initiation and progression of cancers. We tested whether YWHAZ acted as a cancer-promo...
-
Article
Open AccessClinical impact of circulating miR-221 in plasma of patients with pancreatic cancer
Several recent studies have demonstrated that microRNAs (miRNAs) are stably detectable in plasma/serum. We tested miR-221 and miR-375, which are frequently reported to be highly and poorly expressed in pancrea...
-
Article
Open AccessDetection of gastric cancer-associated microRNAs on microRNA microarray comparing pre- and post-operative plasma
Recently, it was reported that plasma microRNAs (miRNAs) are low-invasive useful biomarkers for cancer. We attempted to isolate gastric cancer (GC)-associated miRNAs comparing pre- and post-operative paired pl...
-
Article
Open AccessNovel diagnostic value of circulating miR-18a in plasma of patients with pancreatic cancer
Several recent studies have demonstrated that microRNAs (miRNAs) are stably detectable in the plasma/serum. We hypothesised that miR-18a in the plasma is a potential biomarker in patients with pancreatic cancer.
-
Article
Open AccessCirculating microRNAs in plasma of patients with oesophageal squamous cell carcinoma
Several recent studies demonstrated that microRNAs (miRNAs) are stably detectable in plasma/serum. We hypothesised that plasma miRNAs concentrations contributed to potential biomarkers in patients with oesopha...
-
Article
Open AccessPrediction of CCND1 amplification using plasma DNA as a prognostic marker in oesophageal squamous cell carcinoma
We aimed to develop a new biomarker to predict cyclin D1 (CCND1) status using plasma DNA in oesophageal squamous cell carcinoma (ESCC) patients.
-
Article
Open AccessCirculating microRNAs in plasma of patients with gastric cancers
We examined plasma microRNA (miRNA) concentrations from patients with gastric cancers (GCs) to assess their clinical application for diagnosing and monitoring diseases.
-
Article
Open AccessCombined effects of a third-generation bisphosphonate, zoledronic acid with other anticancer agents against murine osteosarcoma
Bisphosphonates (BPs) are widely used to treat bone diseases and also appear to possess direct antitumour activity. We have previously reported that third-generation BPs such as zoledronic acid (ZOL) and minod...
-
Article
Use of purified beta-tricalcium phosphate for filling defects after curettage of benign bone tumours
Fifty-three patients with benign bone tumours were treated with curettage and filling with a purified beta-tricalcium phosphate (β-TCP). Recurrences occurred in two cases. There was neither a postoperative inf...
-
Article
One-step purification of mammalian deoxyribonucleases I and differences among pancreas, parotid, and pancreas-parotid (mixed) types based on species-and organ-specific N-linked glycosylation
Mammalian deoxyribonucleases I (DNase I) are classified into three types, namely, pancreas, parotid, and pancreas-parotid (mixed), based on differences in their tissue concentrations. In this study, DNase I pu...
-
Article
Recombinant Sendai virus provides a highly efficient gene transfer into human cord blood-derived hematopoietic stem cells
Hematopoietic stem cells (HSCs) are a promising target for gene therapy, however, the low efficiencies of gene transfer using currently available vectors face practical limitations. We have recently developed ...
-
Article
Population structure of loggerhead turtles, Caretta caretta, nesting in Japan: bottlenecks on the Pacific population
Nucleotide sequences from the control region of the mitochondrial (mt) DNA were analyzed for Japanese loggerhead turtles (Caretta caretta) to elucidate population genetic structure and p...
-
Article
A death resulting from inadvertent intravenous infusion of enteral feed
A female patient suffering from the after-effects of an intracerebral hemorrhage, inadvertently received approximately 50 ml of enteral feed containing high molecular weight dextrin intravenously and died 6 h...
-
Article
DNase I Is Present in the Chief Cells of Human and Rat Stomachs
The distribution of deoxyribonuclease I (DNase I) in human and rat stomachs was examined by biochemical, molecular biological and immunohistochemical techniques. By the use of monoclonal anti-human DNase I and...
-
Article
Ceramic endoprosthesis for aggressive giant cell tumors near the knee: eight cases followed for more than 10 years
Eight patients with locally aggressive giant cell tumor were treated with marginal resection and implantation of a ceramic endoprosthesis with a non-hinged knee joint. The patients have been followed-up for be...
-
Article
Postmortem absorption of dichloromethane: a case study and animal experiments
A case of accidental death after occupational exposure to an atmosphere containing dichloromethane (DCM) is reported. The concentrations of DCM in the blood and tissues of a 40-year-old man who died while obs...
-
Article
Open AccessOsteoblastic differentiation and P-glycoprotein multidrug resistance in a murine osteosarcoma model
A recent study of multidrug resistance (MDR) 1 gene transfected osteosarcoma cells found a cause-effect relationship between increased expression of P-glycoprotein (P-gp) and a low aggressive phenotype. Howeve...
