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  1. Article

    Open Access

    Enteric bacterial protein AvrA promotes colonic tumorigenesis and activates colonic beta-catenin signaling pathway

    Salmonella infections can become chronic and increase the risk of cancer. The mechanisms by which specific Salmonella organisms contribute to cancer, however, are still unknown. Live and attenuated Salmonella are...

    R Lu, S Wu, Y-g Zhang, Y **a, X Liu, Y Zheng, H Chen, K L Schaefer, Z Zhou… in Oncogenesis (2014)

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  2. No Access

    Article

    1q gain and CDT2 overexpression underlie an aggressive and highly proliferative form of Ewing sarcoma

    Despite extensive characterization of the role of the EWS-ETS fusions, little is known about secondary genetic alterations and their clinical contribution to Ewing sarcoma (ES). It has been demonstrated that t...

    C Mackintosh, J L Ordóñez, D J García-Domínguez, V Sevillano, A Llombart-Bosch… in Oncogene (2012)

  3. No Access

    Article

    Efficacy of and resistance to anti-IGF-1R therapies in Ewing's sarcoma is dependent on insulin receptor signaling

    Identification of patient selection criteria and understanding of the potential mechanisms involved in the development of resistance are crucial for an appropriate and successful design of clinical trials with...

    C Garofalo, M C Manara, G Nicoletti, M T Marino, P-L Lollini, A Astolfi… in Oncogene (2011)

  4. No Access

    Article

    Hsa-mir-145 is the top EWS-FLI1-repressed microRNA involved in a positive feedback loop in Ewing's sarcoma

    EWS-FLI1 is a chromosome translocation-derived chimeric transcription factor that has a central and rate-limiting role in the pathogenesis of Ewing's sarcoma. Although the EWS-FLI1 transcriptomic signature has...

    J Ban, G Jug, P Mestdagh, R Schwentner, M Kauer, D N T Aryee, K-L Schaefer… in Oncogene (2011)

  5. No Access

    Article

    Suppression of KCMF1 by constitutive high CD99 expression is involved in the migratory ability of Ewing's sarcoma cells

    High CD99 expression levels and rearrangements of the EWS gene with ETS transcription factor genes characterize the Ewing's sarcoma family of tumors (ESFT). CD99 is a cell surface glycoprotein whose engagement ha...

    M Kreppel, D N T Aryee, K-l Schaefer, G Amann, R Kofler, C Poremba, H Kovar in Oncogene (2006)