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  1. No Access

    Article

    WEE1 accumulation and deregulation of S-phase proteins mediate MLN4924 potent inhibitory effect on Ewing sarcoma cells

    Ewing sarcoma (ES) is an aggressive bone and soft tissue tumor of children and young adults in which finding effective new targeted therapies is imperative. Here, we report an in-depth preclinical study of the...

    C Mackintosh, D J García-Domínguez, J L Ordóñez, A Ginel-Picardo, P G Smith… in Oncogene (2013)

  2. No Access

    Article

    1q gain and CDT2 overexpression underlie an aggressive and highly proliferative form of Ewing sarcoma

    Despite extensive characterization of the role of the EWS-ETS fusions, little is known about secondary genetic alterations and their clinical contribution to Ewing sarcoma (ES). It has been demonstrated that t...

    C Mackintosh, J L Ordóñez, D J García-Domínguez, V Sevillano, A Llombart-Bosch… in Oncogene (2012)

  3. Article

    Open Access

    Stable interference of EWS–FLI1 in an Ewing sarcoma cell line impairs IGF-1/IGF-1R signalling and reveals TOPK as a new target

    BACKGROUND: Ewing sarcoma is a paradigm of solid tumour -bearing chromosomal translocations resulting in fusion proteins that act as deregulated transcription factors. Ewing sarcoma translocations fuse the EWS ge...

    D Herrero-Martín, D Osuna, J L Ordóñez, V Sevillano… in British Journal of Cancer (2009)

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