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  1. Article

    Open Access

    EWS-FLI1 perturbs MRTFB/YAP-1/TEAD target gene regulation inhibiting cytoskeletal autoregulatory feedback in Ewing sarcoma

    Ewing sarcoma (EWS) is a paediatric bone cancer with high metastatic potential. Cellular plasticity resulting from dynamic cytoskeletal reorganization, typically regulated via the Rho pathway, is a prerequisit...

    A M Katschnig, M O Kauer, R Schwentner, E M Tomazou, C N Mutz, M Linder… in Oncogene (2017)

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  2. No Access

    Article

    CD99 regulates neural differentiation of Ewing sarcoma cells through miR-34a-Notch-mediated control of NF-κB signaling

    Sarcomas are mesenchymal tumors characterized by blocked differentiation process. In Ewing sarcoma (EWS) both CD99 and EWS-FLI1 concur to oncogenesis and inhibition of differentiation. Here, we demonstrate tha...

    S Ventura, D N T Aryee, F Felicetti, A De Feo, C Mancarella, M C Manara… in Oncogene (2016)

  3. Article

    Open Access

    Suppression of FOXO1 is responsible for a growth regulatory repressive transcriptional sub-signature of EWS-FLI1 in Ewing sarcoma

    The Ewing sarcoma (ES) EWS-FLI1 chimeric oncoprotein is a prototypic aberrant ETS transcription factor with activating and repressive regulatory functions. We report that EWS-FLI1-repressed promoters are enric...

    S Niedan, M Kauer, D N T Aryee, R Kofler, R Schwentner, A Meier, U Pötschger… in Oncogene (2014)

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  4. Article

    Open Access

    Variability in functional p53 reactivation by PRIMA-1Met/APR-246 in Ewing sarcoma

    Though p53 mutations are rare in ES, there is a strong indication that p53 mutant tumours form a particularly bad prognostic group. As such, novel treatment strategies are warranted that would specifically tar...

    D N T Aryee, S Niedan, J Ban, R Schwentner, K Muehlbacher… in British Journal of Cancer (2013)

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  5. No Access

    Article

    Hsa-mir-145 is the top EWS-FLI1-repressed microRNA involved in a positive feedback loop in Ewing's sarcoma

    EWS-FLI1 is a chromosome translocation-derived chimeric transcription factor that has a central and rate-limiting role in the pathogenesis of Ewing's sarcoma. Although the EWS-FLI1 transcriptomic signature has...

    J Ban, G Jug, P Mestdagh, R Schwentner, M Kauer, D N T Aryee, K-L Schaefer… in Oncogene (2011)

  6. No Access

    Article

    O-GlcNAcylation is involved in the transcriptional activity of EWS-FLI1 in Ewing's sarcoma

    The oncogene EWS-FLI1 encodes a chimeric transcription factor expressed in Ewing's sarcoma family tumors (ESFTs). EWS-FLI1 target gene expression is thought to drive ESFT pathogenesis and, therefore, inhibition o...

    R Bachmaier, D N T Aryee, G Jug, M Kauer, M Kreppel, K A Lee, H Kovar in Oncogene (2009)

  7. No Access

    Article

    Suppression of KCMF1 by constitutive high CD99 expression is involved in the migratory ability of Ewing's sarcoma cells

    High CD99 expression levels and rearrangements of the EWS gene with ETS transcription factor genes characterize the Ewing's sarcoma family of tumors (ESFT). CD99 is a cell surface glycoprotein whose engagement ha...

    M Kreppel, D N T Aryee, K-l Schaefer, G Amann, R Kofler, C Poremba, H Kovar in Oncogene (2006)