65 Result(s)

Article

A dominant population of optically invisible massive galaxies in the early Universe

Our current knowledge of cosmic star-formation history during the first two billion years (corresponding to redshift z > 3) is mainly based on galaxies identified in rest-frame ultraviolet light¹. However, this p...

T. Wang, C. Schreiber, D. Elbaz, Y. Yoshimura, K. Kohno, X. Shu, Y. Yamaguchi… in Nature (2019)

Article

The gravitationally unstable gas disk of a starburst galaxy 12 billion years ago

Galaxies in the early Universe that are bright at submillimetre wavelengths (submillimetre-bright galaxies) are forming stars at a rate roughly 1,000 times higher than the Milky Way. A large fraction of the ne...

K. Tadaki, D. Iono, M. S. Yun, I. Aretxaga, B. Hatsukade, D. H. Hughes… in Nature (2018)

Article

Y-box binding protein 1 expression in gastric cancer subtypes and association with cancer neovasculature

Y-box binding protein 1 (YB-1) expression in cancer cells is closely associated with malignant progression and poor prognosis in various cancers. Recently, we demonstrated that YB-1 expression in cancer cells ...

Y. Wu, K.-Y. Wang, Z. Li, Y.-P. Liu, H. Izumi… in Clinical and Translational Oncology (2015)

Article

Long-term remission after high-dose chemotherapy followed by auto-SCT as consolidation for intravascular large B-cell lymphoma

K Kato, Y Ohno, T Kamimura, H Kusumoto, T Tochigi… in Bone Marrow Transplantation (2014)

Article

Two γ-ray bursts from dusty regions with little molecular gas

Emission spectra from the host galaxies of two γ-ray bursts reveal that the regions where the bursts occur are rich in dust but not in molecular gas, which is unexpected because γ-ray bursts are associated wit...

B. Hatsukade, K. Ohta, A. Endo, K. Nakanishi, Y. Tamura, T. Hashimoto, K. Kohno in Nature (2014)

Article

Foscarnet against human herpesvirus (HHV)-6 reactivation after allo-SCT: breakthrough HHV-6 encephalitis following antiviral prophylaxis

High incidences of human herpesvirus (HHV)-6 encephalitis have recently been reported from several Japanese SCT centers. To evaluate the effect of low-dose foscarnet (PFA) in preventing HHV-6 infection among r...

M Ogata, T Satou, Y Inoue, K Takano, T Ikebe, T Ando… in Bone Marrow Transplantation (2013)

Article

Design Evolution of the Spiderweb TES Bolometer for Cosmology Applications

Our group at UC Berkeley has produced the next generation of millimeter-wave spiderweb-absorber transition edge sensor (TES) bolometer technology, which was originally developed for the Atacama Pathfinder Expe...

B. Westbrook, A. Lee, X. Meng, A. Suzuki, K. Arnold… in Journal of Low Temperature Physics (2012)

Article

Overexpression of GalNAc-transferase GalNAc-T3 promotes pancreatic cancer cell growth

O-linked glycans of secreted and membrane-bound proteins have an important role in the pathogenesis of pancreatic cancer by modulating immune responses, inflammation and tumorigenesis. A critical aspect of O-glyc...

K Taniuchi, R L Cerny, A Tanouchi, K Kohno, N Kotani, K Honke, T Saibara… in Oncogene (2011)

Article

Correlations of HHV-6 viral load and plasma IL-6 concentration with HHV-6 encephalitis in allogeneic stem cell transplant recipients

This study investigated factors associated with the development of human herpesvirus (HHV)-6 encephalitis. Among 111 enrolled subjects, 12 patients developed central nervous system (CNS) dysfunction. CNS dysfu...

M Ogata, T Satou, R Kawano, S Takakura, K Goto, J Ikewaki… in Bone Marrow Transplantation (2010)

Article

Twist and p53 reciprocally regulate target genes via direct interaction

Twist is basic helix-loop-helix transcription factor that binds to E-boxes in gene promoters. Twist possesses an oncogenic function by interfering with the tumor suppressor function of p53. Using a membrane pu...

M Shiota, H Izumi, T Onitsuka, N Miyamoto, E Kashiwagi, A Kidani, G Hirano… in Oncogene (2008)

Article

Plasma HHV-6 viral load-guided preemptive therapy against HHV-6 encephalopathy after allogeneic stem cell transplantation: a prospective evaluation

Human herpesvirus 6 (HHV-6) causes life-threatening encephalopathy in recipients of allogeneic SCT, but no consensus has been reached regarding appropriate preventive methods. This study evaluated a plasma HHV...

M Ogata, T Satou, R Kawano, K Goto, J Ikewaki, K Kohno… in Bone Marrow Transplantation (2008)

Article

ZNF143 interacts with p73 and is involved in cisplatin resistance through the transcriptional regulation of DNA repair genes

Zinc-finger protein 143 (ZNF143) is a human homolog of Xenopus transcriptional activator staf that is involved in selenocystyl tRNA transcription. We previously showed that ZNF143 expression is induced by treatme...

T Wakasugi, H Izumi, T Uchiumi, H Suzuki, T Arao, K Nishio, K Kohno in Oncogene (2007)

Article

Clock and ATF4 transcription system regulates drug resistance in human cancer cell lines

The mechanisms underlying cellular drug resistance have been extensively studied, but little is known about its regulation. We have previously reported that activating transcription factor 4 (ATF4) is upregula...

T Igarashi, H Izumi, T Uchiumi, K Nishio, T Arao, M Tanabe, H Uramoto, K Sugio… in Oncogene (2007)

Article

Akt-dependent nuclear localization of Y-box-binding protein 1 in acquisition of malignant characteristics by human ovarian cancer cells

Y-box-binding protein 1 (YB-1), which is a member of the DNA-binding protein family containing a cold-shock domain, has pleiotropic functions in response to various environmental stimuli. As we previously show...

Y Basaki, F Hosoi, Y Oda, A Fotovati, Y Maruyama, S Oie, M Ono, H Izumi… in Oncogene (2007)

Article

Roles of Volume-sensitive Cl⁻ Channel in Cisplatin-induced Apoptosis in Human Epidermoid Cancer Cells

The anti-cancer drug cisplatin induces apoptosis by damaging DNA. Since a stilbene-derivative blocker of Cl⁻/HCO ₃ ⁻ exchangers and Cl⁻ channels, SITS, is know...

T. Ise, T. Shimizu, E.L. Lee, H. Inoue, K. Kohno… in The Journal of Membrane Biology (2005)