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  1. Article

    Induction of EMT-like phenotypes by an active metabolite of leflunomide and its contribution to pulmonary fibrosis

    Drug-induced interstitial lung disease (ILD), particularly pulmonary fibrosis, is a serious clinical concern and myofibroblasts have been suggested to have a major role, with it recently being revealed that so...

    T Namba, K-I Tanaka, Y Ito, T Hoshino, M Matoyama… in Cell Death & Differentiation (2010)

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    Celecoxib upregulates endoplasmic reticulum chaperones that inhibit celecoxib-induced apoptosis in human gastric cells

    Nonsteroidal anti-inflammatory drugs (NSAIDs) induce apoptosis in cancer cells and this effect is involved in their antitumor activity. We recently demonstrated that NSAIDs upregulate GRP78, an endoplasmic ret...

    S Tsutsumi, T Namba, K-I Tanaka, Y Arai, T Ishihara, M Aburaya, S Mima… in Oncogene (2006)

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    Immunohistological observations on pulmonary tissues from dogs infected withDirofilaria immitis

    Pulmonary tissues from non-infected dogs, naturallyDirofilaria immitis-infected dogs and experimentally infected puppies, selectively necropsied after infection, were assessed using peroxidase-antiperoxidase (PAP...

    K. I. Tanaka, R. B. Atwell in Veterinary Research Communications (1993)

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    Structure and reactivity of intermediates. N-overlayer on Pd(100), Rh(100) and Pt-Rh(110) and its reaction with H2

    Rh(100), Pt(100), and Pt-Rh(100) surfaces are inert for the dissociative adsorption of N2, but they are active for the catalytic reaction of NO with H2 During the reaction on Rh(100) and Pt-Rh(100) surfaces, N at...

    K. -I. Tanaka, T. Yamada in Research on Chemical Intermediates (1991)

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    Article

    Mechanism of the ammonia formation from NO-H2. A model study with Pt-Rh alloy single crystal surfaces

    The reduction of NO by H2 was studied over three different Pt-Rh single crystal surfaces, i.e. Pt-Rh(111), (410) and (100). The adsorption and dissociation of NO was studied by HREELS, LEED, XPS, AES and TDS. It ...

    J. Siera, B. E. Nieuwenhuys, H. Hirano, T. Yamada, K. I. Tanaka in Catalysis Letters (1989)