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  1. No Access

    Article

    Haplotype-based, case–control study of the receptor (calcitonin) activity-modifying protein (RAMP) 1 gene in essential hypertension

    The adrenomedullin receptor is a complex molecule that comprises the calcitonin-receptor-like receptor (CRLR) and the receptor-activity-modifying protein (RAMP). RAMP1 is a vasodilation factor, and RAMP1-defic...

    T Nakayama, T Nakazato, H Naruse, Z Fu, Z Wang, M Soma in Journal of Human Hypertension (2017)

  2. No Access

    Chapter

    An Extended Dependability Case to Share Responsibility Knowledge

    Recently, critical incidents have occurred in complex Information Technology (IT) . Thus, how to confirm the dependability of a system using dependability cases is becoming necessary. Information related to d...

    T. Saruwatari, T. Hoshino, S. Yamamoto in Intelligent Decision Technology Support in… (2016)

  3. No Access

    Chapter and Conference Paper

    Full-Potential KKR Calculations for Lattice Distortion of Impurities in Fe-Based Dilute Alloys, Based on the Generalized-Gradient Approximation

    The presence of a point defect in a crystal, such as a vacancy or an impurity atom, generally cause a displacement of the neighboring host atoms from their ideal lattice positions. For examples, the experiment...

    C. Liu, M. Asato, N. Fujima, T. Hoshino in Proceedings of the 8th Pacific Rim Interna… (2016)

  4. Article

    Open Access

    Zidovudine, an anti-viral drug, resensitizes gemcitabine-resistant pancreatic cancer cells to gemcitabine by inhibition of the Akt-GSK3β-Snail pathway

    Pancreatic cancer is one of the most difficult malignancies to treat owing to the rapid acquisition of resistance to chemotherapy. Gemcitabine, a first-line treatment for pancreatic cancer, prolongs patient su...

    T Namba, R Kodama, S Moritomo, T Hoshino, T Mizushima in Cell Death & Disease (2015)

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    Article

    Fission product separation from seawater by electrocoagulation method

    At the Fukushima Daiichi nuclear power station, seawater was urgently injected into the reactor core. Therefore a large amount of seawater containing highly radioactive fission products (FP) accumulated and it...

    T. Kitagaki, T. Hoshino, Y. Sambommatsu in Journal of Radioanalytical and Nuclear Che… (2013)

  6. No Access

    Article

    Structural and electronic properties of Ni5Nb3Zr5 clusters as a local structural unit of Ni-Nb-Zr glassy alloys

    We calculate electronic states of fifty icosahedral Ni5Nb3Zr5 clusters and optimize their structures by first principles calculations within the generalized gradient approximation. Based on the energetic stabili...

    N. Fujima, K. Hara, T. Hoshino, M. Fukuhara in The European Physical Journal D (2011)

  7. No Access

    Article

    Preemptive therapy of human herpesvirus-6 encephalitis with foscarnet sodium for high-risk patients after hematopoietic SCT

    Human herpesvirus-6 (HHV-6) is a major cause of limbic encephalitis with a dismal prognosis after allogeneic hematopoietic SCT (HSCT). A prospective, multicenter study was conducted to assess the safety and ef...

    K Ishiyama, T Katagiri, T Hoshino, T Yoshida, M Yamaguchi in Bone Marrow Transplantation (2011)

  8. Article

    Induction of EMT-like phenotypes by an active metabolite of leflunomide and its contribution to pulmonary fibrosis

    Drug-induced interstitial lung disease (ILD), particularly pulmonary fibrosis, is a serious clinical concern and myofibroblasts have been suggested to have a major role, with it recently being revealed that so...

    T Namba, K-I Tanaka, Y Ito, T Hoshino, M Matoyama in Cell Death & Differentiation (2010)

  9. No Access

    Article

    Successful engraftment of a second transplant from unrelated cord blood identifying acceptable HLA Ag mismatches as treatment for primary graft failure possibly mediated by anti-HLA Abs after ‘mega-dose’ haploidentical PBSC transplantation

    T Hoshino, T Sakura, K Miyawaki, N Hatsumi, S Takada in Bone Marrow Transplantation (2010)

  10. No Access

    Article

    Prophylactic impact of imatinib administration after allogeneic stem cell transplantation on the incidence and severity of chronic graft versus host disease in patients with Philadelphia chromosome-positive leukemia

    H Nakasone, Y Kanda, H Takasaki, C Nakaseko, T Sakura, S Fujisawa, A Yokota in Leukemia (2010)

  11. No Access

    Chapter

    Infiltration of immune cells in salivary gland by IL-18 overexpression in mice

    Sjögren’s syndrome (SS) is a chronic autoimmune disease of the exocrine glands with infiltration of lymphocytes and destruction of glandular cells. We previously reported that interleukin (IL)-18, an inflammat...

    K. Sato, T. Kuroishi, T. Nishioka, Y. Sugawara in Interface Oral Health Science 2007 (2007)

  12. No Access

    Article

    Cerebral blood oxygenation changes induced by bypass blood flow in moyamoya disease and non-moyamoya cerebral ischaemic disease

    Background. Superficial temporal artery–middle cerebral artery (STA–MCA) anastomosis has been used to prevent stroke in patients with moyamoya disease (MD) and non-moyamoya ischaemic disease (non-MD). However, li...

    T. Hoshino, K. Sakatani, T. Kano, Y. Murata, Y. Katayama in Acta Neurochirurgica (2006)

  13. No Access

    Article

    Celecoxib upregulates endoplasmic reticulum chaperones that inhibit celecoxib-induced apoptosis in human gastric cells

    Nonsteroidal anti-inflammatory drugs (NSAIDs) induce apoptosis in cancer cells and this effect is involved in their antitumor activity. We recently demonstrated that NSAIDs upregulate GRP78, an endoplasmic ret...

    S Tsutsumi, T Namba, K-I Tanaka, Y Arai, T Ishihara, M Aburaya, S Mima in Oncogene (2006)

  14. No Access

    Article

    Minilaparotomy approach for colonic cancer: initial experience of 54 cases

    The early outcomes of minilaparotomy for resection of colonic cancer were evaluated.

    H. Ishida, H. Nakada, M. Yokoyama in Surgical Endoscopy And Other Interventiona… (2005)

  15. Article

    Endoplasmic reticulum stress response is involved in nonsteroidal anti-inflammatory drug-induced apoptosis

    Apoptosis induced by nonsteroidal anti-inflammatory drugs (NSAIDs) is involved not only in the production of NSAID-induced gastric lesions but also in the antitumor activity of these drugs. The endoplasmic ret...

    S Tsutsumi, T Gotoh, W Tomisato, S Mima, T Hoshino in Cell Death & Differentiation (2004)

  16. No Access

    Article

    Gasless laparoscopic surgery for ulcerative colitis and familial adenomatous polyposis

    H. Ishida, D. Hashimoto, S. Inokuma in Surgical Endoscopy And Other Interventiona… (2003)

  17. No Access

    Article

    Increased insufflation pressure enhances the development of liver metastasis in a mouse laparoscopy model

    Background: The effect of different insufflation pressures and durations of CO2 pneumoperitoneum on the growth of liver metastasis was investigated in a mouse model. The possible mechanisms involved in the pre...

    H. Ishida, D. Hashimoto, H. Nakada in Surgical Endoscopy And Other Interventiona… (2002)

  18. Article

    Open Access

    Expression of angiogenic factors predicts response to chemoradiotherapy and prognosis of oesophageal squamous cell carcinoma

    The ability to predict patients' responses to chemoradiotherapy by analyzing pre-treatment biopsy specimens would be valuable for managing oesophageal squamous-cell cancer. To this end, the expression of p53, ...

    H Shimada, T Hoshino, S Okazumi, H Matsubara, Y Funami in British Journal of Cancer (2002)

  19. No Access

    Article

    Liver metastases are less established after gasless laparoscopy than after carbon dioxide pneumoperitoneum and laparotomy in a mouse model

    Background: Although the liver is the most frequent site of cancer recurrence after conventional open surgery for colorectal cancer, the effect of laparoscopic procedures with or without gas insufflation on th...

    H. Ishida, D. Hashimoto, I. Takeuchi in Surgical Endoscopy And Other Interventiona… (2002)

  20. No Access

    Article

    Lifetime measurement of the first excited state of 64Ga

    The half-life of the first excited state of 64Ga has been measured with a pulsed beam technique. The half-life was determined to be T 1/2= 21.9 ± 0.7 μs. The corresponding B(E2) = 13.6 ± 0.4 e2fm4 shows good agr...

    M. Tanigaki, K. Sekiguchi, M. Fujita in The European Physical Journal A - Hadrons … (1999)

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