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Article
Haplotype-based, case–control study of the receptor (calcitonin) activity-modifying protein (RAMP) 1 gene in essential hypertension
The adrenomedullin receptor is a complex molecule that comprises the calcitonin-receptor-like receptor (CRLR) and the receptor-activity-modifying protein (RAMP). RAMP1 is a vasodilation factor, and RAMP1-defic...
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Chapter
An Extended Dependability Case to Share Responsibility Knowledge
Recently, critical incidents have occurred in complex Information Technology (IT) . Thus, how to confirm the dependability of a system using dependability cases is becoming necessary. Information related to d...
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Chapter and Conference Paper
Full-Potential KKR Calculations for Lattice Distortion of Impurities in Fe-Based Dilute Alloys, Based on the Generalized-Gradient Approximation
The presence of a point defect in a crystal, such as a vacancy or an impurity atom, generally cause a displacement of the neighboring host atoms from their ideal lattice positions. For examples, the experiment...
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Article
Open AccessZidovudine, an anti-viral drug, resensitizes gemcitabine-resistant pancreatic cancer cells to gemcitabine by inhibition of the Akt-GSK3β-Snail pathway
Pancreatic cancer is one of the most difficult malignancies to treat owing to the rapid acquisition of resistance to chemotherapy. Gemcitabine, a first-line treatment for pancreatic cancer, prolongs patient su...
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Article
Fission product separation from seawater by electrocoagulation method
At the Fukushima Daiichi nuclear power station, seawater was urgently injected into the reactor core. Therefore a large amount of seawater containing highly radioactive fission products (FP) accumulated and it...
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Article
Structural and electronic properties of Ni5Nb3Zr5 clusters as a local structural unit of Ni-Nb-Zr glassy alloys
We calculate electronic states of fifty icosahedral Ni5Nb3Zr5 clusters and optimize their structures by first principles calculations within the generalized gradient approximation. Based on the energetic stabili...
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Article
Preemptive therapy of human herpesvirus-6 encephalitis with foscarnet sodium for high-risk patients after hematopoietic SCT
Human herpesvirus-6 (HHV-6) is a major cause of limbic encephalitis with a dismal prognosis after allogeneic hematopoietic SCT (HSCT). A prospective, multicenter study was conducted to assess the safety and ef...
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Article
Induction of EMT-like phenotypes by an active metabolite of leflunomide and its contribution to pulmonary fibrosis
Drug-induced interstitial lung disease (ILD), particularly pulmonary fibrosis, is a serious clinical concern and myofibroblasts have been suggested to have a major role, with it recently being revealed that so...
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Article
Successful engraftment of a second transplant from unrelated cord blood identifying acceptable HLA Ag mismatches as treatment for primary graft failure possibly mediated by anti-HLA Abs after ‘mega-dose’ haploidentical PBSC transplantation
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Article
Prophylactic impact of imatinib administration after allogeneic stem cell transplantation on the incidence and severity of chronic graft versus host disease in patients with Philadelphia chromosome-positive leukemia
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Chapter
Infiltration of immune cells in salivary gland by IL-18 overexpression in mice
Sjögren’s syndrome (SS) is a chronic autoimmune disease of the exocrine glands with infiltration of lymphocytes and destruction of glandular cells. We previously reported that interleukin (IL)-18, an inflammat...
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Article
Cerebral blood oxygenation changes induced by bypass blood flow in moyamoya disease and non-moyamoya cerebral ischaemic disease
Background. Superficial temporal artery–middle cerebral artery (STA–MCA) anastomosis has been used to prevent stroke in patients with moyamoya disease (MD) and non-moyamoya ischaemic disease (non-MD). However, li...
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Article
Celecoxib upregulates endoplasmic reticulum chaperones that inhibit celecoxib-induced apoptosis in human gastric cells
Nonsteroidal anti-inflammatory drugs (NSAIDs) induce apoptosis in cancer cells and this effect is involved in their antitumor activity. We recently demonstrated that NSAIDs upregulate GRP78, an endoplasmic ret...
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Article
Minilaparotomy approach for colonic cancer: initial experience of 54 cases
The early outcomes of minilaparotomy for resection of colonic cancer were evaluated.
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Article
Endoplasmic reticulum stress response is involved in nonsteroidal anti-inflammatory drug-induced apoptosis
Apoptosis induced by nonsteroidal anti-inflammatory drugs (NSAIDs) is involved not only in the production of NSAID-induced gastric lesions but also in the antitumor activity of these drugs. The endoplasmic ret...
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Article
Gasless laparoscopic surgery for ulcerative colitis and familial adenomatous polyposis
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Article
Increased insufflation pressure enhances the development of liver metastasis in a mouse laparoscopy model
Background: The effect of different insufflation pressures and durations of CO2 pneumoperitoneum on the growth of liver metastasis was investigated in a mouse model. The possible mechanisms involved in the pre...
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Article
Open AccessExpression of angiogenic factors predicts response to chemoradiotherapy and prognosis of oesophageal squamous cell carcinoma
The ability to predict patients' responses to chemoradiotherapy by analyzing pre-treatment biopsy specimens would be valuable for managing oesophageal squamous-cell cancer. To this end, the expression of p53, ...
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Article
Liver metastases are less established after gasless laparoscopy than after carbon dioxide pneumoperitoneum and laparotomy in a mouse model
Background: Although the liver is the most frequent site of cancer recurrence after conventional open surgery for colorectal cancer, the effect of laparoscopic procedures with or without gas insufflation on th...
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Article
Lifetime measurement of the first excited state of 64Ga
The half-life of the first excited state of 64Ga has been measured with a pulsed beam technique. The half-life was determined to be T 1/2= 21.9 ± 0.7 μs. The corresponding B(E2) = 13.6 ± 0.4 e2fm4 shows good agr...