Skip to main content

11 Result(s)

within K Khalili Remove this filter Human Genetics Remove this filter

and

  1. Article

    Erratum: Excision of HIV-1 DNA by gene editing: a proof-of-concept in vivo study

    Correction to: Gene Therapy advance online publication, 19 May 2016; doi: 10.1038/gt.2016.41 The following statement should be noted under Conflict of Interest: 'KK, WH, and RK are named inventors on patents t...

    R Kaminski, R Bella, C Yin, J Otte, P Ferrante, H E Gendelman, H Li… in Gene Therapy (2016)

    Download PDF (33 KB) View Article

  2. No Access

    Article

    Excision of HIV-1 DNA by gene editing: a proof-of-concept in vivo study

    A CRISPR/Cas9 gene editing strategy has been remarkable in excising segments of integrated HIV-1 DNA sequences from the genome of latently infected human cell lines and by introducing InDel mutations, suppress...

    R Kaminski, R Bella, C Yin, J Otte, P Ferrante, H E Gendelman, H Li… in Gene Therapy (2016)

  3. No Access

    Article

    Activation of BAG3 by Egr-1 in response to FGF-2 in neuroblastoma cells

    The co-chaperone protein, BAG3, which belongs to the BAG protein family, has an established antiapoptotic function in different tumor cell lines. Here we demonstrated that treatment of the human neuroblastoma ...

    A Gentilella, G Passiatore, S Deshmane, M C Turco, K Khalili in Oncogene (2008)

  4. No Access

    Article

    Molecular mimicry in inducing DNA damage between HIV-1 Vpr and the anticancer agent, cisplatin

    The human immunodeficiency virus type 1 (HIV-1) viral protein R (vpr) gene is an evolutionarily conserved gene among the primate lentiviruses. Several functions are attributed to Vpr including the ability to caus...

    K Siddiqui, L Del Valle, N Morellet, J Cui, M Ghafouri, R Mukerjee, K Urbanska… in Oncogene (2008)

  5. No Access

    Article

    A novel role of Rac1 GTPase in JCV T-antigen-mediated β-catenin stabilization

    Wnt signaling follows canonical and non-canonical pathways to regulate a variety of processes during cellular homeostasis and development. The large T-antigen (T-Ag) of the human neurotropic JC virus, has been...

    R Bhattacharyya, E K Noch, K Khalili in Oncogene (2007)

  6. No Access

    Article

    Inhibition of IGF-I receptor in anchorage-independence attenuates GSK-3β constitutive phosphorylation and compromises growth and survival of medulloblastoma cell lines

    We have previously reported that insulin-like growth factor-I (IGF-I) supports growth and survival of mouse and human medulloblastoma cell lines, and that IGF-I receptor (IGF-IR) is constitutively phosphorylat...

    K Urbanska, J Trojanek, L Del Valle, M B Eldeen, F Hofmann, C Garcia-Echeverria… in Oncogene (2007)

  7. No Access

    Article

    Interaction of retinoblastoma protein family members with large T-antigen of primate polyomaviruses

    The retinoblastoma gene product pRb and other members of the Rb family of pocket proteins have a central role in the regulation of cell cycle progression. Soon after its discovery, pRb was found to interact wi...

    M K White, K Khalili in Oncogene (2006)

  8. No Access

    Article

    Role of the interaction between large T antigen and Rb family members in the oncogenicity of JC virus

    Human polyomaviruses (JC virus, BK virus and simian virus 40) are causative agents of some human diseases and, interestingly, are involved in processes of cell transformation and oncogenesis. These viruses nee...

    V Caracciolo, K Reiss, K Khalili, G De Falco, A Giordano in Oncogene (2006)

  9. No Access

    Article

    p27SJ, a novel protein in St John's Wort, that suppresses expression of HIV-1 genome

    Transcription of the HIV-1 genome is controlled by the cooperation of viral regulatory proteins and several host factors which bind to specific DNA sequences within the viral promoter spanning the long termina...

    N Darbinian-Sarkissian, A Darbinyan, J Otte, S Radhakrishnan, B E Sawaya… in Gene Therapy (2006)

  10. No Access

    Article

    Genomic analysis of Th1–Th2 cytokine genes in an AIDS cohort: identification of IL4 and IL10 haplotypes associated with the disease progression

    Polymorphisms of Th1–Th2 cytokine genes have previously been implicated in the rate of progression to AIDS in seropositive patients. To evaluate further the impact of these genes in the development of AIDS, we...

    A Vasilescu, S C Heath, R Ivanova, H Hendel, H Do, A Mazoyer… in Genes & Immunity (2003)

  11. No Access

    Article

    Suppression of HIV-1 transcription and replication by a Vpr mutant

    Vpr, the 96 amino acid long protein represents one of the auxiliary proteins of human immunodeficiency virus type-1 (HIV-1), which exhibits the ability to increase the rate of replication of the virus in T cel...

    B E Sawaya, K Khalili, J Rappaport, D Serio, W Chen, A Srinivasan, S Amini in Gene Therapy (1999)