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Article
Interaction of retinoblastoma protein family members with large T-antigen of primate polyomaviruses
The retinoblastoma gene product pRb and other members of the Rb family of pocket proteins have a central role in the regulation of cell cycle progression. Soon after its discovery, pRb was found to interact wi...
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Article
Small-molecule inhibitors of signal transduction pathways in leukemia therapeutics: how to assess selectivity for malignant signals
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Article
Requirement for the PI3K/Akt pathway in MEK1-mediated growth and prevention of apoptosis: identification of an Achilles heel in leukemia
The Raf/MEK/ERK kinase cascade plays a critical role in transducing growth signals from activated cell surface receptors. Using ΔMEK1:ER, a conditionally active form of MEK1 which responds to either β-estradiol o...
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Chapter and Conference Paper
Some Tumour Markers in Malignant and Non-Malignant Hybrid Cells
The use of positron emission tomography is of great potential in the detection of tumors. This report reviews recent studies on particular physiological and biochemical markers that appear to have a good corre...
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Article
Hexose transport in hybrids between malignant and normal cells
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Article
Hexose transport in hybrids between malignant and normal cells
The kinetic parameters of hexose uptake were measured in matched pairs of hybrids between malignant and normal cells. Each pair consisted of a hybrid in which malignancy was initially suppressed and a segregan...
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Article
The fatigue properties of cross-plied boron 6061 aluminium
The mechanical properties of 0/90° and 0/90/+-45° boron-aluminium laminates have been examined at room temperature, 200 and 300° C. The increase in test temperature resulted in decreases in both the tensile an...
