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Article
Open AccessNardilysin-regulated scission mechanism activates polo-like kinase 3 to suppress the development of pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) develops through step-wise genetic and molecular alterations including Kras mutation and inactivation of various apoptotic pathways. Here, we find that development of ap...
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Protocol
Detection of Gasdermin C-Mediated Cancer Cell Pyroptosis
Gasdermin proteins except DFNB59 are the executioners of pyroptotic cell death. Cleavage of a gasdermin by an active protease causes lytic cell death. Gasdermin C (GSDMC) is cleaved by caspase-8 in response to...
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Article
Author Correction: PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis
Although pyroptosis is critical for macrophages against pathogen infection, its role and mechanism in cancer cells remains unclear. PD-L1 has been detected in the nucleus, with unknown function. Here we show t...
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Article
Microwave method synthesis of magnetic ionic liquid/gold nanoparticles as ultrasensitive SERS substrates for trace clopidol detection
Clopidol is one of the most widely used anti-coccidiosis drugs. Its residues in poultry products and the environment pose a serious threat to human health. In this work, microwave-assisted synthesis of magneti...
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Article
Open AccessAuthor Correction: CDK2-mediated site-specific phosphorylation of EZH2 drives and maintains triple-negative breast cancer
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessCDK2-mediated site-specific phosphorylation of EZH2 drives and maintains triple-negative breast cancer
Triple-negative breast cancer (TNBC), which lacks estrogen receptor α (ERα), progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression, is closely related to basal-like breast cance...
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Article
Palmitoylation stabilizes PD-L1 to promote breast tumor growth
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Article
Exosomal PD-L1 harbors active defense function to suppress T cell killing of breast cancer cells and promote tumor growth
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Article
Open AccessA new unconventional HLA-A2-restricted epitope from HBV core protein elicits antiviral cytotoxic T lymphocytes
Cytotoxic T cells (CTLs) play a key role in the control of Hepatitis B virus (HBV) infection and viral clearance. However, most of identified CTL epitopes are derived from HBV of genotypes A and D, and few hav...
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Chapter and Conference Paper
A Peer Selection Algorithm Based on Tolerance and Behavior Capacity in P2P Streaming Media System
Considering the long start-up delay and load unbalance, based on the relation model between user behavior and peer selection, a Peer Selection algorithm based on Tolerance and Behavior Capacity (PSTBC) in P2P ...
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Article
Car-Parinello molecular dynamics simulations of thionitroxide and S-nitrosothiol in the gas phase, methanol, and water—A theoretical study of S-nitrosylation
A dilemma about whether thionitroxide radical (RSNHO) or S-nitrosothiol (RSNO) is observed in protein S-nitrosylation has arisen recently. To illustrate the effect of chemical environment on these structures, thi...
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Article
Open AccessSynthesis and characterization of high density and high aspect ratio Ag2S nanoparticle nanowires from a paired cell method
Ag2S nanoparticle nanowires were prepared in a porous anodic aluminum oxide template by a simple paired cell method, and were characterized by XRD, FESEM, HRTEM and EDS. The results showed that the as-prepared na...
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Article
Fault Detection and Automated Fault Diagnosis for Embedded Integrated Electrical Passives
In this paper, we propose a novel test technique for fault detection and automated fault diagnosis using pole/zero analysis of embedded integrated passives. For performing pole/zero analysis, an ensemble of ci...
