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Article
Open AccessElucidating the characteristics of Mx1 and resistance to influenza A virus subtype H1N1 in the newly developed KWM/Hym mice
Inbred mice have several advantages, including genetic similarity to humans, a well-established gene manipulation system, and strong tolerance to inbreeding. However, inbred mice derived from a limited genetic...
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Article
Open AccessSex differences in glucose metabolism of streptozotocin-induced diabetes inbred mice (C57BL/6J)
Considering that sex differences in glucose metabolism are observed in mice, researchers unconsciously use male mice to reduce variations by an estrogen cycle in female mice. In this study, we investigated the...
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Article
Open AccessDelayed onset of obesity and glucose tolerance in interleukin 18 deficient mice by single housed condition
Interleukin 18 (IL18) is a kind of proinflammatory cytokine that belongs to the interleukin-1 family. IL18 is associated with obesity and type 2 diabetes. To discover whether body composition parameters in IL1...
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Article
Open AccessGenetic and morphometric characteristics of Korean wild mice (KWM/Hym) captured at Chuncheon, South Korea
Laboratory inbred mice are used widely and commonly in biomedical research, but inbred mice do not have a big enough gene pool for the research. In this study, genetic and morphometric analyses were performed ...
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Article
Aged black garlic extract regulates lipid metabolism by inhibiting lipogenesis and promoting lipolysis in mature 3T3-L1 adipocytes
As the mechanism of aged black garlic (ABG) extract affecting lipid metabolism in adipocytes remains unclear, this study evaluated the effect of ABG extract on lipid metabolism and the expression of related pr...
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Article
Open AccessOver-expression of myosin7A in cochlear hair cells of circling mice
Circling mouse (C57BL/6J-cir/cir) deleted the transmembrane inner ear (Tmie) gene is an animal model for human non-syndromic recessive deafness, DFNB6. In circling mouse, hair cells in the cochlea have degenerate...
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Article
Open AccessFine tuning of Rac1 and RhoA alters cuspal shapes by remolding the cellular geometry
The anatomic and functional combinations of cusps and lophs (ridges) define the tooth shape of rodent molars, which distinguishes species. The species-specific cusp patterns result from the spatiotemporal indu...
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Article
Open AccessErratum to: Rapid and efficient identification of the mouse leptin receptor mutation (C57BLKS/J-Leprdb) by tetra-primer amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) analysis
We designed 4 primers for amplification of allelespecific PCR products from leptin receptor mutant and normal alleles using primer design web service for tetraprimer ARMS-PCR (Figure 1) i.e., Lepr-forward oute...
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Article
Open AccessRapid and efficient identification of the mouse leptin receptor mutation (C57BL/KsJ-db/db) by tetra-primer amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) analysis
The C57BLKS/J-Leprdb mouse has a point mutation in the leptin receptor gene and is one of the most useful animal model for non-insulin dependent diabetes mellitus in human. Since the homozygote of C57BLKS/J-Leprd...
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Article
Anti-adipogenic effects in 3T3-L1 cells of acetone extracts and fractions from Styrax japonica fruit
Reduction in reactive oxygen species (ROS) production facilitated by Styrax japonica (SJ) extracts and fractions for inhibition of obesity development through inhibition of adipogenesis was investigated. Treatmen...
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Article
Effect of interactions between genetic polymorphisms and cigarette smoking on plasma triglyceride levels in elderly Koreans: the Hallym Aging Study
High triglyceride (TG) levels are known to be associated with complex diseases such as cardiovascular disease. Here, we evaluated the effect of interactions between genetic polymorphisms and environmental fact...
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Article
Comparison of N-Methyl-d-aspartate Receptor Subunit 1 and 4-Hydroxynonenal in the Hippocampus of Natural and Chemical-Induced Aging Accelerated Mice
In this study, we compared N-methyl-d-aspartate receptor type 1 (NMDAR1) and 4-hydroxynonenal (4-HNE) in the hippocampus of d-galactose (d-gal)-induced and naturally aging models of mice. These markers represent...
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Article
Genetic risk assessment for cardiovascular disease with seven genes associated with plasma C-reactive protein concentrations in Asian populations
Plasma C-reactive protein (CRP) level is a predictor of cardiovascular risk. We performed a meta-analysis on the effect of 12 single-nucleotide polymorphisms (SNPs) within 8 candidate loci in 36 752 Asians. In...
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Article
Anti-obesity effects of the stem bark of Japanese horse chestnut (Aesculus turbinate) in 3T3-L1 preadipocytes
The inhibitory effects of lipid accumulation on ethanol extract from stem bark of Japanese horse chestnut (JHC) were evaluated. Exposure to JHC extract (10–100 μg/mL) for a 72 h incubation period did not alter...
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Article
Analyses of longitudinal effects of gene-environment interactions on plasma C-reactive protein levels: the Hallym Aging Study
High C-reactive protein (CRP) level (above 3 mg/L), an inflammatory biomarker, is a well-known risk factor for cardiovascular disease. We investigated the longitudinal effects of interaction between genetic va...
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Article
Anti-diabetic effect of the soybean extract fermented by Bacillus subtilis MORI in db/db mice
This study investigated the effects of soy bean extract fermented by Bacillus subtilis MORI (BTD-1) on blood glucose, hemoglobin A1c (HbA1c), plasma insulin, and pancreatic β islets in db/db mice. The BTD-1 (500 ...
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Article
Open AccessProduction of antibodies with peptide-CpG-DNA-liposome complex without carriers
The screening of peptide-based epitopes has been studied extensively for the purpose of develo** therapeutic antibodies and prophylactic vaccines that can be potentially useful for treating cancer and infect...
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Article
A New Variant of the Mouse Akp1 Locus
A new electrophoretic migration type of alkaline phosphatase 1 (Akp1) was found on the cellulose acetate electrophoresis for kidney and liver homogenates of KWHM mouse, a newly established inbred strain derived f...
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Article
Quantitative trait loci for proteinuria in the focal glomerulosclerosis mouse model
The FGS/Kist strain of mice, a new animal model for focal glomerulosclerosis (FGS) in humans, was previously established by recurrent selection for high proteinuria, which is a principal marker of FGS, from de...
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Article
Age-related change of neuropeptide Y-immunoreactive neurons in the rat anterior olfactory nucleus
Neuropeptide Y (NPY) is located in the olfactory system, including the olfactory bulb, and is thought to be one of the main neurotransmitters for olfaction. Thus, we examined age-related changes of NPY-immunor...
