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Article
Open AccessLongitudinal multi-omics analysis of host microbiome architecture and immune responses during short-term spaceflight
Maintenance of astronaut health during spaceflight will require monitoring and potentially modulating their microbiomes. However, documenting microbial shifts during spaceflight has been difficult due to missi...
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Article
Open AccessEthical considerations for the age of non-governmental space exploration
Mounting ambitions and capabilities for public and private, non-government sector crewed space exploration bring with them an increasingly diverse set of space travelers, raising new and nontrivial ethical, le...
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Article
Open AccessSpaceflight induces changes in gene expression profiles linked to insulin and estrogen
Organismal adaptations to spaceflight have been characterized at the molecular level in model organisms, including Drosophila and C. elegans. Here, we extend molecular work to energy metabolism and sex hormone si...
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Article
Open AccessSpatiotemporal expression and control of haemoglobin in space
It is now widely recognised that the environment in space activates a diverse set of genes involved in regulating fundamental cellular pathways. This includes the activation of genes associated with blood home...
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Article
MCAST'S Aerospace Program in Malta: An Overview of Technological Advancements and International Collaborations
The Aerospace Program at the Malta College of Arts, Science and Technology (MCAST) is a research and development program that focuses on addressing challenges in the aerospace industry, in particular, but not ...
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Article
Maltese Allelic Variants in Corneal Dystrophy Genes in a Worldwide Setting
This study aimed to establish which worldwide population cohorts have a genetic make-up closest to that of a large sample of the Maltese population with regard to corneal dystrophy (CD) genes.
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Article
Open AccessEpigenomic analysis of KLF1 haploinsufficiency in primary human erythroblasts
Haploinsufficiency for the erythroid-specific transcription factor KLF1 is associated with hereditary persistence of fetal hemoglobin (HPFH). Increased HbF ameliorates the symptoms of β-hemoglobinopathies and ...
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Article
Open AccessNovel leukocyte-depleted platelet-rich plasma-based skin equivalent as an in vitro model of chronic wounds: a preliminary study
Chronic leg ulcerations are associated with Haemoglobin disorders, Type2 Diabetes Mellitus, and long-term venous insufficiency, where poor perfusion and altered metabolism develop into a chronic inflammation t...
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Article
Open AccessAspirin impairs acetyl-coenzyme A metabolism in redox-compromised yeast cells
Aspirin is a widely used anti-inflammatory and antithrombotic drug also known in recent years for its promising chemopreventive antineoplastic properties, thought to be mediated in part by its ability to induc...
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Article
Open AccessNovel genetic risk variants for pediatric celiac disease
Celiac disease is a complex chronic immune-mediated disorder of the small intestine. Today, the pathobiology of the disease is unclear, perplexing differential diagnosis, patient stratification, and decision-m...
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Article
Open AccessIdentification of cancer predisposition variants in apparently healthy individuals using a next-generation sequencing-based family genomics approach
Cancer, like many common disorders, has a complex etiology, often with a strong genetic component and with multiple environmental factors contributing to susceptibility. A considerable number of genomic varian...
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Article
Open AccessSystematic documentation and analysis of human genetic variation in hemoglobinopathies using the microattribution approach
George Patrinos and colleagues report the first implementation of the microattribution approach to systematically document genetic variation associated with a disease, applied here to hemoglobinopathies and th...
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Article
Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin
Sjaak Philipsen and colleagues report that haploinsufficiency for KLF1 causes hereditary persistence of fetal hemoglobin in a large Maltese family. They further show that KLF1 is a key activator of BCL11A, whi...
