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Open AccessConformational gating, dynamics and allostery in human monoacylglycerol lipase
Inhibition of human Monoacylglycerol Lipase (hMGL) offers a novel approach for treating neurological diseases. The design of inhibitors, targeting active-inactive conformational transitions of the enzyme, can ...
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Open AccessChip-to-Chip Authentication Method Based on SRAM PUF and Public Key Cryptography
In today’s globalized integrated circuit (IC) ecosystem, untrusted foundries are often procured to build critical systems since they offer state-of-the-art silicon with the best performance available. On the o...
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Open AccessEffects of Distal Mutations on the Structure, Dynamics and Catalysis of Human Monoacylglycerol Lipase
An understanding of how conformational dynamics modulates function and catalysis of human monoacylglycerol lipase (hMGL), an important pharmaceutical target, can facilitate the development of novel ligands wit...
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Open AccessIdentification of cancer predisposition variants in apparently healthy individuals using a next-generation sequencing-based family genomics approach
Cancer, like many common disorders, has a complex etiology, often with a strong genetic component and with multiple environmental factors contributing to susceptibility. A considerable number of genomic varian...
