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Article
Open AccessLongitudinal multi-omics analysis of host microbiome architecture and immune responses during short-term spaceflight
Maintenance of astronaut health during spaceflight will require monitoring and potentially modulating their microbiomes. However, documenting microbial shifts during spaceflight has been difficult due to missi...
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Article
Open AccessSecretome profiling reveals acute changes in oxidative stress, brain homeostasis, and coagulation following short-duration spaceflight
As spaceflight becomes more common with commercial crews, blood-based measures of crew health can guide both astronaut biomedicine and countermeasures. By profiling plasma proteins, metabolites, and extracellu...
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Article
Open AccessCollection of biospecimens from the inspiration4 mission establishes the standards for the space omics and medical atlas (SOMA)
The SpaceX Inspiration4 mission provided a unique opportunity to study the impact of spaceflight on the human body. Biospecimen samples were collected from four crew members longitudinally before (Launch: L-92...
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Open AccessDirect RNA sequencing of astronaut blood reveals spaceflight-associated m6A increases and hematopoietic transcriptional responses
The advent of civilian spaceflight challenges scientists to precisely describe the effects of spaceflight on human physiology, particularly at the molecular and cellular level. Newer, nanopore-based sequencing...
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Article
Open AccessSpatial multi-omics of human skin reveals KRAS and inflammatory responses to spaceflight
Spaceflight can change metabolic, immunological, and biological homeostasis and cause skin rashes and irritation, yet the molecular basis remains unclear. To investigate the impact of short-duration spacefligh...
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Article
Open AccessSingle-cell multi-ome and immune profiles of the Inspiration4 crew reveal conserved, cell-type, and sex-specific responses to spaceflight
Spaceflight induces an immune response in astronauts. To better characterize this effect, we generated single-cell, multi-ome, cell-free RNA (cfRNA), biochemical, and hematology data for the SpaceX Inspiration...
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Article
Open AccessInspiration4 data access through the NASA Open Science Data Repository
The increasing accessibility of commercial and private space travel necessitates a profound understanding of its impact on human health. The NASA Open Science Data Repository (OSDR) provides transparent and FA...
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Article
Open AccessImmunological and hematological outcomes following protracted low dose/low dose rate ionizing radiation and simulated microgravity
Using a ground-based model to simulate spaceflight [21-days of single-housed, hindlimb unloading (HLU) combined with continuous low-dose gamma irradiation (LDR, total dose of 0.04 Gy)], an in-depth survey of t...
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Article
Open AccessSpaceflight influences gene expression, photoreceptor integrity, and oxidative stress-related damage in the murine retina
Extended spaceflight has been shown to adversely affect astronaut visual acuity. The purpose of this study was to determine whether spaceflight alters gene expression profiles and induces oxidative damage in t...
